Contribution of the Cholinergic Innervation to Early Memory Development in the Neonate Para-Hippocampal System

  • Alexandre Pitti
  • Yasuo Kuniyoshi
Conference paper


Newborns present impressive developmental changes during the first year in almost all domains marked by memory categorization and variability. We propose that one important actor of this developmental shift is the gradual influence of the cholinergic system in the cortico-hippocampal circuits. Based on neurological observations and developmental studies, we model how the neuromodulator acetylcholine could be gradually released in the hippocampal system from the fetal period till the first year to support the detection of novel signals and the encoding of memories. By doing so, we suggest that the cholinergic system realizes the functional reorganization of the cortico-hippocampal system as a working memory for novelty.


Entorhinal Cortex Cholinergic System Synaptic Weight Cholinergic Activation Cholinergic Innervation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors would like to thank professor Ichiro Tsuda for his valuables comments and remarks.


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Laboratoire ETIS, UMR 8051Universite de Cergy-PontoiseCergy-PontoiseFrance
  2. 2.Laboratory for Intelligent Systems and Informatics, Department of Mechano-InformaticsUniversity of TokyoTokyoJapan

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