Contribution of the Cholinergic Innervation to Early Memory Development in the Neonate Para-Hippocampal System
Newborns present impressive developmental changes during the first year in almost all domains marked by memory categorization and variability. We propose that one important actor of this developmental shift is the gradual influence of the cholinergic system in the cortico-hippocampal circuits. Based on neurological observations and developmental studies, we model how the neuromodulator acetylcholine could be gradually released in the hippocampal system from the fetal period till the first year to support the detection of novel signals and the encoding of memories. By doing so, we suggest that the cholinergic system realizes the functional reorganization of the cortico-hippocampal system as a working memory for novelty.
KeywordsEntorhinal Cortex Cholinergic System Synaptic Weight Cholinergic Activation Cholinergic Innervation
The authors would like to thank professor Ichiro Tsuda for his valuables comments and remarks.
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