Towards a Modeling and Simulation Platform for Multi-level Neuronal Networks

  • Yoshiyuki Asai
  • Hideki Oka
  • Taishin Nomura
  • Hiroaki Kitano
Conference paper


We have been developing an open platform for enhancing the integrative life science called Physiome and systems biology, on which users can build mathematical models of biological and physiological functions with hierarchical structure, and perform simulations with parallel computing. We also have been proposing a XML-based language for describing a wide variety of models, and developing a model database in order to facilitate model sharing. Neuroscience is one of the research fields in which mathematical models played effectively important roles to reveal physiological principles. We will discuss on a possibility to apply our platform for neuroscience.


Membrane Potential Dynamic SBML Model Functional Edge Ionic Current Module Model Description Language 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work is supported in part by MEXT Global COE program at Osaka University, and Grant-in-Aid for Scientific Research on Innovative Areas at Osaka university and at OIST.


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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • Yoshiyuki Asai
    • 1
  • Hideki Oka
    • 2
  • Taishin Nomura
    • 2
    • 3
  • Hiroaki Kitano
    • 1
    • 4
    • 5
  1. 1.Open Biology UnitOkinawa Institute of Science and TechnologyOkinawaJapan
  2. 2.The Center for Advanced Medical Engineering and InformaticsOsaka UniversityOsakaJapan
  3. 3.Department of Mechanical Science and Bioengineering, Graduate School of Engineering ScienceOsaka UniversityOsakaJapan
  4. 4.The Systems Biology InstituteTokyoJapan
  5. 5.Sony Computer Science LaboratoriesTokyoJapan

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