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Regulation of Metastasis by miRNAs

  • Suresh K. Alahari
Chapter

Abstract

A breakthrough of the twenty-first century is the discovery in which protein expression is regulated by a new class of endogenous, noncoding, small RNAs (microRNAs). These microRNAs (miRNAs) control gene expression by acting on their target mRNAs, inducing either mRNA degradation or translational repression. MiRNAs are single-stranded and highly conserved between species. MiRNAs have been implicated in the detection and treatment of various pathological states. In the genome, most miRNAs are much smaller than protein coding genes, but they have specific functions in various biological processes. The major process in cancer progression is metastasis. Metastatic processes include invasion, intravasation, and extravasation. In this chapter, we introduce basic information about miRNAs, their functional mechanism, and their biological roles in tumor metastasis.

Keywords

Breast Cancer Primary Tumor Growth Metastatic Breast Cancer Cell NMuMG Cell Nonsmall Cell Lung Carcinoma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgments

I would like to thank Samthosh Alahari for editorial help, and members of my lab for intellectual help. This work was supported by grants from NIH, Susan Komen Foundation and Louisiana Cancer Research Consortium.

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© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Department of Biochemistry and Molecular BiologyStanley S. Scott Cancer Center, LSU School of MedicineNew OrleansUSA

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