G Protein Coupled Receptors

  • Andrea Strasser
  • Hans-Joachim Wittmann


G protein coupled receptors play an important role due to physiological and pathophysiological processes and are responsible for signal transduction in the cell. Furthermore, about 30 % of drugs, present on market, address G protein coupled receptors. First, the families for classification of G protein coupled receptors are presented. Additionally, it is introduced into conformational changes of the receptors during the activation process by an agonist and into the interaction of the receptors with heterotrimeric G proteins. Besides that, a short overview of signal cascades in dependence of the type of the Ga subunit is given.

Internet sources of GPCR network are mentioned.


Conformational Change Lipid Bilayer Protein Couple Receptor Transmembrane Receptor Extracellular Loop 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.Institute of Pharmacy, Dept. of Pharm./Med. ChemistryUniversity of RegensburgRegensburgGermany
  2. 2.Faculty of Chemistry and PharmacyUniversity of RegensburgRegensburgGermany

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