G Protein Coupled Receptors
G protein coupled receptors play an important role due to physiological and pathophysiological processes and are responsible for signal transduction in the cell. Furthermore, about 30 % of drugs, present on market, address G protein coupled receptors. First, the families for classification of G protein coupled receptors are presented. Additionally, it is introduced into conformational changes of the receptors during the activation process by an agonist and into the interaction of the receptors with heterotrimeric G proteins. Besides that, a short overview of signal cascades in dependence of the type of the Ga subunit is given.
Internet sources of GPCR network are mentioned.