Phytochemicals and Amino Acids: Inducers or Inhibitors of Cell Death?

  • Asser Ghoneim


Phytochemicals and amino acids have long been considered as important inducers of cell death. However, many of these natural compounds have been demonstrating dual action effects on cell death through inhibition as well as induction. Clinical applications may require dosage adjustment and determination of selectively vulnerable cells, either normal or cancer cells. Indeed, the opposing actions and controversial uses as cytoprotective and/or cytotoxic agents, in different tissues and diseases, need further scrutiny. The potential usefulness of these natural compounds as combined chemoprotectants for cancer chemotherapy should also be taken into consideration. Special emphasis will be placed on curcumin and Astragalus constituents as potential phytochemicals. Relevant amino acids include the excitatory and branched-chain ones, as well as glycine and cysteine.


Mantle Cell Lymphoma Active Constituent Necrotic Cell Death Antiapoptotic Effect Maple Syrup Urine Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The author is greatly indebted to Dr. Aya Asaad, Professor of Pharmacognosy, Faculty of Pharmacy, Alexandria University, for reading and commenting on the manuscript.


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© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.Department of Pharmacology and Toxicology, Faculty of PharmacyDamanhour University (formerly Alexandria University, Damanhour Branch)DamanhourEgypt

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