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Archaeal Orc1/Cdc6 Proteins

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The Eukaryotic Replisome: a Guide to Protein Structure and Function

Part of the book series: Subcellular Biochemistry ((SCBI,volume 62))

Abstract

The initiation of DNA replication in most archaeal genomes is mediated by proteins related to eukaryotic Orc1 and Cdc6. Archaeal replication origins have been mapped and their interactions with Orc1/Cdc6 proteins have been characterized at the biochemical level. Structural and biophysical studies have revealed the basic rules of sequence recognition by archaeal initiators.

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Acknowledgements

I thank Marek Drozdz and Rachel Samson for their comments on this chapter. I would also like to thank Alessandro Costa for valuable discussions on the role of ATP in these proteins. Work in my lab is supported by the EPA Trust, Wellcome Trust and BBSRC.

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Authors and Affiliations

  1. Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford, OX1 3RE, UK

    Stephen D. Bell

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  1. Stephen D. Bell
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Correspondence to Stephen D. Bell .

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Editors and Affiliations

  1. , School of Biology, University of St Andrews, Biomedical Sciences Research Complex, North Haugh, St Andrews, KY16 9ST, Fife, United Kingdom

    Stuart MacNeill

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Bell, S.D. (2012). Archaeal Orc1/Cdc6 Proteins. In: MacNeill, S. (eds) The Eukaryotic Replisome: a Guide to Protein Structure and Function. Subcellular Biochemistry, vol 62. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4572-8_4

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