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Influence of Sera from Interstitial Lung Disease Patients on Angiogenic Activity of Mononuclear Cells

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Book cover Respiratory Regulation - The Molecular Approach

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 756))

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Abstract

Chronic inflammation stimulates of neovascularization. The aim of this study was to evaluate the effect of sera from interstitial lung diseases (ILD) patients on angiogenic capabilities of different subsets of mononuclear cells. Serum samples were obtained from 22 patients with sarcoidosis, 20 with hypersensitivity pneumonitis, 20 with idiopathic pulmonary fibrosis, 9 with systemic sclerosis, 6 with pulmonary Langerhans cells histiocytosis, and from 20 healthy volunteers. Animal model of leukocyte induced angiogenesis assay was used as an angiogenic test. The pattern of angiogenic reaction was different in different diseases. Sera from systemic sclerosis and pulmonary Langerhans cells histiocytosis patients exerted inhibitory effects on angiogenesis, but sera from sarcoidosis, hypersensitivity pneumonitis, and idiopathic pulmonary fibrosis patients stimulated angiogenesis. Sera from sarcoidosis and pulmonary Langerhans cells histiocytosis primed monocytes for the production of angiogenic factors. The number of microvessels created after incubation of mononuclear cells depleted of monocytes with sera from systemic sclerosis patients significantly decreased. We conclude that the role of monocytes in the modulation of angiogenesis varies depending on the type of ILD. Sera from sarcoidosis stimulate and from pulmonary Langerhans cells histiocytosis patients inhibit neovascularization induced by monocyte mediators. Sera from systemic sclerosis inhibit angiogenesis induced by lymphocyte products.

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Acknowledgments

Supported by an internal grant of the Institute of Tuberculosis and Lung Diseases in Warsaw.

Conflicts of interest: No conflict of interest was declared with relation to this work.

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Authors and Affiliations

  1. Department of Family Medicine, Medical University of Warsaw, Banacha 1a St, 02-097, Warsaw, Poland

    T. M. Zielonka, K. Zycinska & M. H. Obrowski

  2. Department of Lung Diseases, Institute of Tuberculosis and Lung Diseases, Plocka 26 St, 01-138, Warsaw, Poland

    E. Radzikowska

  3. Department of Laboratory Diagnostics and Immunology, Institute of Tuberculosis and Lung Diseases, Plocka 26 St, 01-138, Warsaw, Poland

    M. Filewska & B. Bialas

  4. Department of Pathology, Biostructure Center, Medical University of Warsaw, Chalubinskiego 5 St, 02-004, Warsaw, Poland

    E. Skopinska-Rozewska

  5. Department of Laboratory Diagnostics and Clinical Immunology of the Developmental Age, Medical University of Warsaw, Marszalkowska 24 St, 00-576, Warsaw, Poland

    U. Demkow

Authors
  1. T. M. Zielonka
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  2. K. Zycinska
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  3. E. Radzikowska
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  4. M. Filewska
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  7. E. Skopinska-Rozewska
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Correspondence to T. M. Zielonka .

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Editors and Affiliations

  1. Medical Research Center, Respiratory Research, Polish Academy of Sciences, Pawinskiego 5, Warsaw, 02-106, Poland

    Mieczyslaw Pokorski

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Zielonka, T.M. et al. (2013). Influence of Sera from Interstitial Lung Disease Patients on Angiogenic Activity of Mononuclear Cells. In: Pokorski, M. (eds) Respiratory Regulation - The Molecular Approach. Advances in Experimental Medicine and Biology, vol 756. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4549-0_18

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