Comparing In Silico Results to In Vivo and Ex Vivo of Influenza-Specific Immune Responses After Vaccination or Infection in Humans
In this chapter we describe a computer simulation system focused on the immune response. The objective of this study is to show to what extent a computational model can be used as an in silico tool to compare alternative vaccine formulations, to show strengths and weaknesses of this approach and to identify points of intervention to improve biological fidelity of the results. The model gives an example of how to conduct biomedical research by using mathematical and computational methods to evaluate hypotheses and to predict clinical outcomes. Specifically, we show that prime-boost vaccination protocols can be modeled and used to elucidate the protective role of the immune memory elicited by priming with either influenza vaccines or influenza infection.
KeywordsH1N1 Computer simulation Prime-boost vaccination S-OIV Epitope prediction
The authors are thankful to Frederic Vogel for insightful comments and suggestions.
- Burnet FM (1959) The clonal selection theory of acquired immunity. Vanderbuil University press, NashvilleGoogle Scholar
- Castiglione F (2009) Agent based modeling and simulation, introduction to. In: Meyers R (ed) Encyclopedia of complexity and systems science, vol 1. Springer, New YorkGoogle Scholar
- Goldsby RA, Kindt TJ, Kuby J, Osborne BA (2000) Kuby immunology, 4th edn. W.H. Freeman & Company, New YorkGoogle Scholar
- Jerne NK (1974) Towards a network theory of the immune system. Ann Immunol 125C:373–389Google Scholar
- Kaplan HS (1980) Hodgkin’s disease, 2nd edn. Harvard University Press, Cambridge, MAGoogle Scholar
- Murphy K, Travers P, Walport M (2007) Janeway’s immunobiology, 7th edn. Garland Science, New York/LondonGoogle Scholar
- Murphy K, Travers P, Janeway C, Walport M (2008) Janeway’s immunology. Garland Science/Taylor & Francis, New YorkGoogle Scholar
- Nakaya HI, Wrammert J, Lee EK, Racioppi L, Marie-Kunze S, Haining WN, Means AR, Kasturi SP, Khan N, Li G-M, McCausland M, Kanchan V, Kokko KE, Li S, Elbein R, Mehta AK, Aderem A, Subbarao K, Ahmed R, Pulendran B (2011) Systems biology of vaccination for seasonal influenza in humans. Nat Immunol 12:786–795PubMedCrossRefGoogle Scholar
- Nowak MA, May RM (2000) Virus dynamics: mathematical principles of immunology and virology. Oxford University Press, Oxford, XIIGoogle Scholar
- Wolfram S (2002) A New kind of science. Wolfram Media, ChampainGoogle Scholar