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The Importance of Animal Models in the Development of Vaccines

  • Tadele G. Kiros
  • Benoît Levast
  • Gaël Auray
  • Stacy Strom
  • Jill van Kessel
  • Volker GerdtsEmail author
Chapter

Abstract

Efficient translation of basic vaccine research into clinical therapies greatly depends upon the availability of appropriate animal models. Testing novel vaccine candidates in animal models is a critical step in the development of modern vaccines. Animal models are being used to assess the quality and quantity of the immune response, to identify the optimal route of delivery and formulation, to determine protection from infection and disease transmission, and to evaluate the safety and toxicity of the vaccine formulation. Animal models help to make the translation from basic research to clinical application, and they often allow prediction of the vaccine potential, which helps in predicting the financial risks for vaccine manufacturers. Choosing an appropriate animal model has become increasingly important for the field, as each model has its own advantages and disadvantages. In this review, the criteria for selecting the right animal model, the advantages and disadvantages of various animal models, as well as the future needs for animal models are being discussed.

Keywords

Animal model Vaccine development Vaccine delivery Infectious disease 

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Tadele G. Kiros
    • 1
  • Benoît Levast
    • 1
  • Gaël Auray
    • 1
  • Stacy Strom
    • 1
  • Jill van Kessel
    • 1
  • Volker Gerdts
    • 1
    Email author
  1. 1.Vaccine and Infectious Disease Organization-InterVac, and Department of Veterinary MicrobiologyUniversity of SaskatchewanSaskatoonCanada

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