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Systems Metabolic Engineering of Corynebacterium glutamicum for Biobased Production of Chemicals, Materials and Fuels

Chapter

Abstract

Systems metabolic engineering integrates systems wide understanding of biological systems with targeted genetic modification towards optimum production performance. Supported by novel powerful tools and technologies from systems biology, strategies for industrial strain engineering evolve more and more from trial and error into knowledge based rational development. For the soil bacterium Corynebacterium glutamicum, a working horse in industrial biotechnology since more than 50 years, this opens a broad avenue to create and shape a versatile cell factory with superior properties for many purposes. As reviewed in this chapter, applications of systems metabolic engineering to C. glutamicum deeply open the new era of sustainable bio-economy with various chemicals, materials and fuels obtained from renewable feed stocks. Additionally, a first example from lysine production gives a flavor on the next future level of strain engineering, i.e. synthetic metabolic engineering, enabling genome scale models and synthetic biology for a priori global strain design.

Keywords

Metabolic engineering Corynebacterium glutamicum Chemicals Bio-materials Bio-fuels Genetic engineering Strain engineering Industrial biotechnology Fluxomics Systems biology Synthetic biology Sustainable bio-economy Renewable feedstocks Model-based design Hemicellulose Xylose Arabinose Cellobiose Glycerol Silage Starch Whey Amino acids Lysine Glutamate Methionine Valine Serine Tryptophan Vitamins Flavor Fragrances Diamines Diaminopentane Diaminobutane Succinic acid Propanediol, Ethanol Isobutanol Rational Strain design Metabolic model Multi omics Sugar assimilation Biosynthesis Model prediction Genome breeding Cadaverine Putrescine 

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Judith Becker
    • 1
  • Stefanie Kind
    • 1
  • Christoph Wittmann
    • 1
  1. 1.Institute of Biochemical EngineeringTechnische Universität BraunschweigBraunschweigGermany

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