Pediatric Medullomyoblastoma: Immunohistochemical Analyses

  • Masaki UenoEmail author
  • Masayuki Onodera
  • Takashi Kusaka
  • Reiji Haba
  • Takashi Tamiya
  • Haruhiko Sakamoto
Part of the Pediatric Cancer book series (PECA, volume 3)


Medullomyoblastoma is a rare embryonal tumor of the central nervous system and is classified as medulloblastoma with myogenic differentiation according to the most recent WHO classification, 4th edition. The tumor cells have neuroectodermal and myoblastic features. The origin of the myoblastic element of MMB remains to be completely clarified. We reported a case of a 3-year-old girl with medullomyoblastoma in the cerebellar vermis. She underwent total resection of the tumor, followed by chemotherapy and radiotherapy in the brain and spinal cord. The resected specimen mainly consisted of densely packed cells with round-to-oval highly chromatic nuclei surrounded by scanty cytoplasm (indicating neuroectodermal differentiation) and focally of long spindle-shaped cells with elongated nuclei and eosinophilic cytoplasm showing discernible cross-striations (indicating myoblastic differentiation). In addition, the tumor cells showed large nuclei with nucleolus, frequent mitoses, apoptoses, nuclear molding, and cell wrapping, indicating moderate anaplasia. Immunohistochemical staining revealed partial expression of myoglobin and desmin as well as synaptophysin and neurofilament in the tumor cells. Some tumor cells showed double immunopositivity for synaptophysin and myoglobin, suggesting the idea that the neuroectodermal cells may undergo differentiation into rhabdomyoblasts.


Glial Fibrillary Acidic Protein Myogenic Differentiation Malignant Teratoma Classic Medulloblastoma Malignant Central Nervous System Tumor 
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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Masaki Ueno
    • 1
    Email author
  • Masayuki Onodera
    • 1
  • Takashi Kusaka
    • 2
  • Reiji Haba
    • 3
  • Takashi Tamiya
    • 4
  • Haruhiko Sakamoto
    • 1
  1. 1.Department of Pathology and Host Defense, Faculty of MedicineKagawa UniversityKagawaJapan
  2. 2.Maternal Perinatal Center, Faculty of MedicineKagawa UniversityKagawaJapan
  3. 3.Department of Diagnostic Pathology, Faculty of MedicineKagawa UniversityKagawaJapan
  4. 4.Department of Neurological Surgery, Faculty of MedicineKagawa UniversityKagawaJapan

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