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Juvenile Hormone Biosynthetic Enzymes as Targets for Insecticide Discovery

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Advanced Technologies for Managing Insect Pests

Abstract

Juvenile hormone (JH) plays important roles in insect morphogenesis and reproduction. For this reason, interfering with its biosynthesis has long been considered a promising strategy for the development of target-specific insecticides. Although several inhibitors of JH biosynthetic enzymes have been developed, none have yet been used operationally for the management of insect pests. However, recent progress in the fields of molecular biology and structural bioinformatics has made it possible to clone and characterize key JH biosynthetic enzymes, opening the way to the rational design of highly specific and effective enzyme inhibitors. In addition, the discovery of insect-produced peptides that inhibit JH biosynthesis, the allatostatins, has led to the development of peptide analogs that inhibit JH biosynthesis in vivo, offering an alternative approach for interfering with JH production. This chapter provides an overview of the JH biosynthetic pathway as well as a synthesis of both early and recent work on the development of inhibitors of JH biosynthesis. We also review recent work aimed at the cloning and characterization of JH biosynthetic enzymes.

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Acknowledgments

We thank two anonymous reviewers for their constructive comments on an earlier version of the manuscript. Some of the research reviewed in this chapter was supported by grants from the Natural Sciences and Engineering Research Council of Canada and Natural Resources Canada to M.C. and from the National Science Foundation to S.E.S.

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Authors and Affiliations

  1. Natural Resources Canada, Canadian Forest Service, Laurentian Forestry Centre, Quebec City, QC, GIV 4C7, Canada

    Michel Cusson

  2. Department of Chemistry, The College of New Jersey, Ewing, NJ, 08628-0718, USA

    Stephanie E. Sen

  3. Division of Insect Sciences, National Institute of Agrobiological Sciences, Tsukuba, Ibaraki, Japan

    Tetsuro Shinoda

Authors
  1. Michel Cusson
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  2. Stephanie E. Sen
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  3. Tetsuro Shinoda
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Correspondence to Michel Cusson .

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Editors and Affiliations

  1. The Volcani Center, Dept. of Entomology, Agricultural Research Organization, s/n, Bet Dagan, 50250, Israel

    Isaac Ishaaya

  2. College of Agriculture, Entomology, University of Kentucky, s/n, Lexington, 40546, Kentucky, USA

    Subba Reddy Palli

  3. , Entomology, Gilat Research Center, M.P. Negev, Gilat, 85280, Israel

    A. Rami Horowitz

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© 2013 Her Majesty the Queen in Right of Canada, represented by the Minister of Natural Resources

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Cusson, M., Sen, S.E., Shinoda, T. (2013). Juvenile Hormone Biosynthetic Enzymes as Targets for Insecticide Discovery. In: Ishaaya, I., Palli, S., Horowitz, A. (eds) Advanced Technologies for Managing Insect Pests. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4497-4_3

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