Environmental Pathology

  • José A. Centeno
  • Florabel G. Mullick
  • Kamal G. Ishak
  • Teri J. Franks
  • Allen P. Burke
  • Michael N. Koss
  • Daniel P. Perl
  • Paul B. Tchounwou
  • Joseph P. Pestaner


Humans are constantly exposed to hazardous pollutants in the environment—for example, in the air, water, soil, rocks, diet, or workplace. Trace metals are important in environmental pathology because of the wide range of toxic reactions and their potential adverse effects on the physiological function of organ systems. Exposures to toxic trace metals have been the subject of numerous environmental and geochemical investigations, and many studies have been published on the acute and/or chronic effects of high-level exposures to these types of agents; however, much fewer data are available concerning the health effects of low-dose chronic exposure to many trace metals. Chronic low-dose exposures to toxic elements such as cadmium and arsenic have been shown to cause these metals to accumulate in tissues over time, leading to multiple adverse effects in exposed individuals.


Dilate Cardiomyopathy Iron Overload Lead Exposure Asbestos Exposure Selenium Deficiency 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors would like to express their appreciation to Drs. Elena Ladich, Todor Todorov, Leonor Martinez, Elizabeth Meze, and Linda Murakata for their valuable contributions during the preparation of this chapter.

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Copyright information

© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  • José A. Centeno
    • 1
  • Florabel G. Mullick
    • 2
  • Kamal G. Ishak
  • Teri J. Franks
    • 2
  • Allen P. Burke
    • 2
  • Michael N. Koss
    • 3
  • Daniel P. Perl
    • 4
  • Paul B. Tchounwou
    • 5
  • Joseph P. Pestaner
    • 6
  1. 1.Joint Pathology Center Division of Biophysical ToxicologyMalcolm Grow Medical Clinic Joint Base Andrews Air Naval FacilityWashingtonUSA
  2. 2.The Joint Pathology Center Silver SpringSilver SpringUSA
  3. 3.Medical LaboratoriesUniversity of Southern California Medical CenterLos AngelesUSA
  4. 4.Department of NeurologyUniformed Services University of the Health SciencesBethesdaUSA
  5. 5.College of Science, Engineering and TechnologyJackson State UniversityJacksonUSA
  6. 6.Medical Examiner OfficeWashingtonUSA

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