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The Impact of Micronutrient Deficiencies inThe Impact of Micronutrient Deficiencies in Agricultural Soils and Crops on the Nutritional Health of Humans

  • Marija Knez
  • Robin D. Graham
Chapter

Abstract

Cereal crops underpin the food supply for peasant farmers in developing countries, a situation that has persisted since the green revolution of the decades of the 1960s and 1970s greatly increased their productivity; indeed yields more than doubled. Ever since, the modern high-yielding, disease-resistant cereals that also show greater tolerance to environmental stresses like drought and heat have dominated the diets of subsistence farmers and urban poor alike.

Keywords

Phytic Acid Iodine Deficiency Micronutrient Deficiency Maple Syrup Urine Disease Hepcidin Expression 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Abbo S, Grusak MA, Tzuk T, Reifen R (2000) Genetic control of seed weight and calcium concentration in chickpea seed. Plant Breed 119:427–431CrossRefGoogle Scholar
  2. Agius F et al (2003) Engineering increased vitamin C levels in plants by overexpression of a D-galacturonic acid reductase. Nature 21:177–181CrossRefGoogle Scholar
  3. Anderson A (1981) Nat Food Inst 52 (Soberg, Denmark)Google Scholar
  4. Anderson VP, Jack S, Monchy D, Hem N, Hok P, Bailey KB, Gibson RS (2008) Co-existing micronutrient deficiencies among stunted Cambodian infants and toddlers. Asia Pac J Clin Nutr 17(1):72–9Google Scholar
  5. Andrews N (1999) Disorders of iron metabolism. N Engl J Med 341:1986–1995CrossRefGoogle Scholar
  6. Baik H, Russell RM (1999) Vitamin B12 deficiency and elderly. Annu Rev Nutr 19:357–377CrossRefGoogle Scholar
  7. Barceloux DG (1999) Zinc. Clin Toxicol 37:279–292Google Scholar
  8. Beck FW, Kaplan J, Fitzgerald JT, Brewer GJ (1997) Changes in cytokine production and T cell subpopulations in experimentally induced zinc-deficient humans. Am J Physiol 272:E1002–E1007Google Scholar
  9. Bertinato J, Iskandar M, L'Abbe RM (2003) Copper deficiency induces the upragulation of the copper chaperone for Cu/Zn superoxide dismutase in weaning male rats. J Nutr 133(1):28–31Google Scholar
  10. Blair MW, Astudillo C, Grusak M, Graham R, Beebe S (2009) Inheritance of seed iron and zinc content in common bean (Phaseolus vulgaris L.). Mol Breed 23:197–207Google Scholar
  11. Bleackley R, MacGillivray RT (2011) Transition metal homeostasis: from yeast to human disease. Biometals 24:785–809CrossRefGoogle Scholar
  12. Bohn T, Davidsson T, Walczyk T, Hurrell RF (2004) Phytic acid added to white-wheat bread inhibits fractional apparent magnesium absorption in humans. Am J Clin Nutr Rev 79:418–423Google Scholar
  13. Bouis HE, Welch RM (2010) Biofortification—a sustainable agricultural strategy for reducing micronutrient malnutrition in the global South. Crop Sci 50:S20–S32CrossRefGoogle Scholar
  14. Bowman B, Kwakye GF, Hernandez HE, Aschner M (2011) Role of manganese in neurogenerative diseases. J Trace Elem Med Biol 25(4):191–203CrossRefGoogle Scholar
  15. Bryce J et al (2008) Maternal and child undernutrition 4: effective action at the national level. The Lancet 371:510–526Google Scholar
  16. Cakmak I (2009) Enrichment of fertilizers with zinc: an excellent investment for humanity and crop production in India. J Trace Elem Med Biol 23(4):281–289CrossRefGoogle Scholar
  17. Calesnick B, Dinan AM (1988) Zinc deficiency and zinc toxicity. Am Fam Physician 37:267–270Google Scholar
  18. Cao X-Y et al (1994) Iodination of irrigation water as a method of supplying iodine to a severely iodine-deficient population in XinJiang, China. Lancet 344(8915):107–110CrossRefGoogle Scholar
  19. Calloway DH (1995) Human nutrition: food and micronutrient relationships. International Food Policy Research Institute, Washington, DCGoogle Scholar
  20. Carmel R (2007) Haptocorrin (transcobalamin I) and cobalamin deficiencies. Clin Chem 53(2):367–368CrossRefGoogle Scholar
  21. Cartwright G, Wintrobe MM (1964) Copper metabolism in normal subjects. Am J Clin Nutr Rev 14:224–232Google Scholar
  22. Clark LC, Combs GF, Turnbull BW, Slate EH, Chalker DK, Chow J et al (1996) Effects of selenium supplementation for cancer prevention in patients with carcinoma of the skin. JAMA 276:1957–1963CrossRefGoogle Scholar
  23. Cordano A (1998) Clinical manifestation of nutritional copper deficiency in infants and children. Am J Clin Nutr 67:1012S–1016SGoogle Scholar
  24. Danzeisen R, Fosset C, Chariana Z, Page K, David S, McArdle HJ (2002) Placental ceruloplasmin homolog is regulated by iron and copper and is implicated in iron metabolism. Am J Physiol Cell Physiol 282:C472–C478Google Scholar
  25. Darshan D, Anderson GJ (2009) Interacting signals in the control of hepcidin expression. Biometals 22:77–87CrossRefGoogle Scholar
  26. Davis C, Greger JL (1992) Longitudinal changes of manganese-dependent superoxide dismutase and other indexes of manganese and iron status in women. Am J Clin Nutr 55:747–752Google Scholar
  27. De Walle H, De Jong-Van Den Berg LT (2002) Insufficient folic acid intake in the Netherlands: what about the future? Teratology 66(1):40–43CrossRefGoogle Scholar
  28. Dijkhuizen MA, Wieringa FT, West CE, Martuti S, Muhilal (2001) Effects of iron and zinc supplementation in Indonesian infants on micronutrient status and growth. J Nutr 131:2860–5Google Scholar
  29. Diplock A (1992) Selenium, antioxidant nutritions, and human diseases. Biol Trace Elem Res 33:155–156CrossRefGoogle Scholar
  30. Duxbury MA, Bodruzzaman M, Lauren JM, Sadat RM, Welch N, E-Elahi, Meisner CA (2005) Increasing wheat and rice productivity in the sub-tropics using micronutrient enriched seed. In: Andersen P. et al (ed) Micronutrients in South and South East Asia. Proceedings of international workshop, Kathmandu, Nepal. 8-11 Sept 2004. International Centre for Integrated Mountain Development (ICIMOD), Kathmandu, pp 187–198Google Scholar
  31. Edison S, Bajel A, Chandy M (2008) Iron homeostasis: new players, newer insights. Eur J Haemotol 81:411–424CrossRefGoogle Scholar
  32. Egli I, Davidsson L, Zeder C, Walczyk T, Hurrell R (2004) Dephytinization of a complementary food based on wheat and soy increases zinc, but not copper, apparent absorption in adults. J Nutr 134:1077–1080Google Scholar
  33. Eide D, Broderius M, Fett J, Guerinot ML (1996) A novel iron-regulated metal transporter from plants identified by functional expression in yeast. Proc Natl Acad Sci USA 93:5624–5628CrossRefGoogle Scholar
  34. Elkhalil A, Osman HA, Osman O (2011) Phytic acid analysis by different bacterial phytases. Aust J Basic Appl Sci 5(11):2295–2302Google Scholar
  35. Flood V, Mitchell P (2007) Folate and vitamin B12 in older Australians. Med J Aus 186:321–322Google Scholar
  36. Freeland-Graves J, Lianis C (1994) Models to study manganese deficiency. In: Klimis-Tavantzis DJ (ed) Manganese in health and disease. CRC Press, Boca Raton, pp 59–86Google Scholar
  37. Friedman BJ, Freeland-Graves J, Bales CA et al (1987) Manganese balance and clinical observations in young men fed a manganese-deficient die. J Nutr 117(1):133–143Google Scholar
  38. Genc C, Verbyla AP, Torun AA, Cakmak I, Willsmore K, Wallwork H, McDonald GK (2009) Quantitative trait loci analysis of zinc efficiency and grain zinc concentration in wheat using whole genome average interval mapping. Plant Soil 314:49–66Google Scholar
  39. Gibson RS (2003) Concurrent micronutrient deficiencies in developing countries: problems and solutions. Proc Nutr Soc 28:21–34Google Scholar
  40. Gibson R (2005) Principles of nutritional assessment, 2nd edn. Oxford University Press, OxfordGoogle Scholar
  41. Goh J, Morain CA (2003) Nutrition and adult inflammatory bowel disease. Aliment Pharmacol Ther 17(3):307–320CrossRefGoogle Scholar
  42. Graham RD (1984) Breeding for nutritional characteristics in cereals. Adv Plant Nutr 1:57–102Google Scholar
  43. Graham RD (2008) Micronutrient deficiencies in crops and their global significance Chapter 2. In: Alloway BJ (ed) Micronutrient deficiencies in global crop productionGoogle Scholar
  44. Graham CG, Cardano A (1939) Copper depletion and deficiency in the malnourished infant. John Hopkins Med J 124:139–150Google Scholar
  45. Graham RD, Stangoulis JCR (2001) Trace element uptake and distribution in plants. J Nutr 133(5):1502S–1505SGoogle Scholar
  46. Graham RD, Welch RM (1996) Breeding for staple food crops with high micronutrient density. International Food Policy Research Institute, Washington, DCGoogle Scholar
  47. Graham RD, Ascher JS, Ellis PAE, Shepherd KW (1987) Transfer to wheat of the copper efficiency factor carried on rye chromosome arm 5RL. Plant Soil 99:107–114Google Scholar
  48. Graham RD, Welch RM, Saunders DA, Ortiz-Monasterio I, Bouis HE, Bonierbale M, de Haan S, Burgos G, Thiele G, Liria R, Meisner CA, Beebe SE, Potts MJ, Kadian M, Hobbs PR, Gupta RK, Twomlow S (2007) Nutritious subsistence food systems. Adv Agron 92:1–74CrossRefGoogle Scholar
  49. Graham RD (2008) Micronutrient deficiencies in crops and their global significance. Chapter 2 in Alloway BJ (ed) Micronutrient deficiencies in global crop production (pp. 41–61), Dordrecht, SpringerGoogle Scholar
  50. Graham RD, Knez M, Welch RM (2012) How much nutritional iron deficiency in humans globally is due to an underlying zinc deficiency? Adv Agron 115:1–40CrossRefGoogle Scholar
  51. Gromer S, Eubel JK, Lee BL, Jacob J (2005) Human selenoproteins at a glance. Cell Mol Life Sci 62(21):2414–2437CrossRefGoogle Scholar
  52. Grotz N, Fox T, Connolly E, Park W, Guerinot ML, Eide D (1998) Identification of a family of zinc transporter genes from Arabidopsis that respond to zinc deficiency. Proc Natl Acad Sci USA 95:7220–7224CrossRefGoogle Scholar
  53. Grusak M (2002) Enhancing mineral content in plant food products. J Am Coll Nutr 21(3):178S–183SGoogle Scholar
  54. Guttieri MJ et al (2006) Agronomic performance of low phytic acid wheat. Crop Sci 46:2623–2629CrossRefGoogle Scholar
  55. Haas E (2001) Selenium. Health world on-line available at: http://www.healthy.net/scr/article.aspx?ID=2068
  56. Hambidge M (2000) Human zinc deficiency. J Nutr 130:1344S–1349SGoogle Scholar
  57. Hathcock J (1997) Vitamins and minerals: efficacy and safety. Am J Clin Nutr 66:427–437Google Scholar
  58. Hentze M, Muckenthaler MU, Andrews NC (2004) Balancing acts: molecular control of mammalian iron metabolism. Cell 117(3):285–297CrossRefGoogle Scholar
  59. Hirsch IK (1999) Expression of Arabidopsis CAX1 in tobacco: altered calcium homeostasis and increased stress sensitivity. Plant Cell 11:2113–2122Google Scholar
  60. Hotz C, Brown KM (2004) Assessment of the risk of zinc deficiency in populations and options for its control. Food Nutr Bull 25:S99–S199Google Scholar
  61. Huynh B, Mather DE, Wallwork H, Graham RD, Welch RM, Stangoulis JCR (2008) Genotypic variation in wheat grain fructan content revealed by a simplified HPLC method. J Cereal Sci 48:369–378CrossRefGoogle Scholar
  62. ICCIDD (2011) International council for the control of iodine deficiency disorders. http://www.iccidd.org/
  63. Iwaya H, Kashiwaya M, Shinoki A, Lee JS, Hayashi K, Hara H, Ishizuka S (2011) Marginal zinc deficiency exacerbates experimental colitis induced by dextran sulfate sodium in rats. J Nutr 141(6):1077–1082CrossRefGoogle Scholar
  64. Joyce C, Deneau A, Peterson K, Ockenden I, Raboy V, Lott JNA (2005) The concentrations and distributions of phytic acid phosphorus and other mineral nutrients in wild-type and low phytic acid Js-12-LPA wheat (Triticum aestivum) grain parts. Can J Bot 83(12):1599–1607Google Scholar
  65. Kawashima Y et al (2001) Dietary zinc-deficiency and its recovery responses in rat liver cytosolic alcohol dehydrogenase activities. J Toxicol Sci 36:101–108CrossRefGoogle Scholar
  66. Keen CL (1996) Teratogenic effects of essential trace metals: Deficiencies and excesses. In: Chang L, Magos L, Suzuki T (eds) Toxicology of metals. CRC Press Inc, New York, pp 997–1001Google Scholar
  67. Keen CL, Uriu-Hare JY, Hawk SN, Jankowski MA, Daston GP, Kwik-Uribe CL, Rucker RB (1998) Effect of copper deficiency on prenatal development and pregnancy outcome. Am J Clin Nutr 67:1003S–1011SGoogle Scholar
  68. Keen C et al (2003) The plausability of micronutrient deficiencies being a significant contributing factor to the occurrence of pregnancy complications. J Nutr 133(5):1597S–1605SGoogle Scholar
  69. Kennedy C, Nantel G, Shetty P (2003) The scourge of hidden hunger: global dimensions of micronutrient deficiencies. FAO Food, Nutr Agric 32:15–16Google Scholar
  70. Khabaz-Saberi H, Graham RD, Pallotta MA, Rathjen AJ, Williams KJ (2002). Genetic markers for manganese efficiency in durum wheat (Triticum turgidum L. var. durum). Plant Breed 121:224–22Google Scholar
  71. Khan A et al (2012) Ascorbic acid: an enigmatic molecule to development and enviromental stress in plants. Int J Appl Technol 2(3):97–111Google Scholar
  72. Lederer J (1986) Sélenium et Vitamine E, Jouvence, FranceGoogle Scholar
  73. Liu T (2003) Selenium. Chem Eng News 81(36):94CrossRefGoogle Scholar
  74. Lonnerdal B, Uauy R (1998) Genetic and environmental determinants of copper metabolism. Am J Clin Nutr 67:951Google Scholar
  75. Lonnerdal B, Sandberg AS, Sandstrom B, Kunz C (1989) Inhibitory effects of phytic acid and other inositol phosphates on zinc and calcium absorption in suckling rats. J Nutr 119:211–214Google Scholar
  76. Lonergan PF, Pallotta MA, Lorimer M, Paull JG, Barker SJ, Graham RD (2009) Multiple genetic loci for zinc uptake and distribution in barley (Hordeum vulgare). New Phytol 184:168–179Google Scholar
  77. Lucca P, Hurrell R, Potrykus I (2001) Genetic engineering approaches to improve the bioavailability and the level of iron in rice grains. Theor Appl Genet 102:392–397CrossRefGoogle Scholar
  78. Lynch S (1997) Interaction of iron with other nutrients. Nutr Rev 55(4):102–110CrossRefGoogle Scholar
  79. Lyons GL, Stangoulis JCR, Graham RD (2004) Exploiting micronutrient interaction to optimize biofortification programs: the case for inclusion of selenium and iodine in the harvest plus program. Nutr Rev 62:247–252Google Scholar
  80. Markle W, Fisher MA, Smego RA (2007) Understanding global health. McGraw-Hill Medicall, New YorkGoogle Scholar
  81. Miller W (2006) Extrathyroidal benefits of iodine. J Am Physician Surg 11(4):106–110Google Scholar
  82. Milne D (1998) Copper intake and assessment of copper status. Am J Clin Nutr 67:1041S–1045SGoogle Scholar
  83. Mocchegiani E, Giacconi R, Muzzioli M, Cipriano C (2000) Zinc, infections and immunosenescence. Mech Ageing Dev 121(1–3):21–35Google Scholar
  84. Navarro-Alarcon M, Cabrera-Vique C (2008) Selenium in food and the human body: a review. Sci Total Environ 400:115–141CrossRefGoogle Scholar
  85. Nestel P, Bouis HE, Meenakshi JV, Wolfgang P (2006) Biofortification of staple food crops. Am Soc Nutr 136(4):1064–1067Google Scholar
  86. Nguyen Van Lam H, Wallwork H, Stangoulis CRJ (2011) Identification of quantitative trait loci for grain arabinoxylan concentration in bread wheat. Crop Sci 51(3):1143–1150CrossRefGoogle Scholar
  87. Prasad AS (1963) Zinc and iron deficiencies in male subjects with dwarfism and hypogonadism but without ancylostomiasia, schistosomiasis or severe anemia. Am J Clin Nutr 12:437–444Google Scholar
  88. Prasad AS (1991) Discovery of human zinc deficiency and studies in an experimental human model. Am J Clin Nutr 53:403–412Google Scholar
  89. Prasad AS (2002) Zinc deficiency in patients with sickle cell disease. Am J Clin Nutr 75:181–182Google Scholar
  90. Prasad AS (2003) Zinc deficiency. BMJ 326:409–410CrossRefGoogle Scholar
  91. Prentice AM et al (2008) New challenges in studying nutrition disease interactions in the developing world. J Clin Invest 118:1322–1329CrossRefGoogle Scholar
  92. Raiten J et al (2011) Executive summary—biomarkers of nutrition for development: building a consensus. The Am Clin Nutr 94(2):633S–650SCrossRefGoogle Scholar
  93. Ramakrishnan U, Cossio GT, Neufeld ML, Rivera J, Martorell R (2004) Multimicronutrient interventions but not vitamin A or iron interventions alone can improve child growth: results of 3 meta analyses. J Nutr 134:2592–2602Google Scholar
  94. Rayman M (2000) The importance of selenium for human health. Lancet 356:233–241CrossRefGoogle Scholar
  95. Reuter DJ, Robinson JB (1997) Plant analysis: an interpretation manual 2nd edn CSIRO Publishing, MelbourneGoogle Scholar
  96. Rickes EL, Brink NG, Koniuszy FR, Wood TR, Folkers K (1948) Crystalline vitamin B12. Sci Total Environ 107:396Google Scholar
  97. Rimbach G, Pallauf J, Moehring J, Kraemer K, Minihane MA (2008) Effect of dietary phytate and microbial phytase on mineral and trace element bioavailability, a literature review. Curr Top Nutraceutical Res 6(3):131–144Google Scholar
  98. Robertfoid M (2005) Introducing inulin-type fructans. Br J Nutr 9:S13–S25CrossRefGoogle Scholar
  99. Robinson N, Procter CM, Connolly EL, Guerinot ML (1999) A ferricchelate reductase for iron uptake from soils. Nature 397:694–697CrossRefGoogle Scholar
  100. Roy C (2010) Anemia of inflammation. Hematology 30:276–280CrossRefGoogle Scholar
  101. Sager M (2006) Selenium in agriculture, food and nutrition. Pure Appl Chem 78:111–133CrossRefGoogle Scholar
  102. Schwarz K, Foltz CM (1957) Selenium as an integral part of factor-3 against dietary necrotic liver degeneration. J Am Chem Soc 79:3292–3293CrossRefGoogle Scholar
  103. Seatharam B, Alpers DH (1982) Absorption and transport of cobalamin (vitamin B12). Ann Rev Nutr 2:343–349CrossRefGoogle Scholar
  104. Shoham S, Youdim MB (2002) The effect of iron deficiency and iron and zinc supplementation on rat hippocampus ferritin. J Neural Transm 109:1241–1256CrossRefGoogle Scholar
  105. Singh M (2004) Role of micronutrients for physical growth and mental development. Indian J Pediatr 71(1):59–62Google Scholar
  106. Sillanpaa (1990) Micronutient assessment at country level: an international study. FAO Soils Bulletin No.63 FAO, RomeGoogle Scholar
  107. Sohail S, Roland AD (1999) Fabulous phytase: phytase enzyme proving helpful to poultry producers and environment. Highlight Agric Res 1(46)Google Scholar
  108. Steele M, Frazer DM, Anderson AJ (2005) Systematic regulation of intestinal iron absorption. Life 57:499–503Google Scholar
  109. Stewart CP et al (2010) The undernutrition epidemic: an urgent health priority. Lancet 375:282CrossRefGoogle Scholar
  110. Subramanian KB, Bharathi C, Jegan A (2008) Response of maize to mycorrhizal colonization at varying levels of zinc and phosphorus. Biol Fertil Soils 45(2):133–144CrossRefGoogle Scholar
  111. Trowel L (1973) Definition of dietary fiber and hypotheses that it is a protective factor in certain diseases. Am J Clin Nutr 26:417–427Google Scholar
  112. Turnlund J (1998) Human whole-body copper metabolism. Am J Clin Nutr 67:960S–964SGoogle Scholar
  113. Turnlund JR, Keyes WR, Peiffer GL, Scott KC (1998) Copper absorption, excretion and retention by young men consuming low dietary copper determined by using the stable isotope 65Cu. Am J Clin Nutr 67:1219–1225Google Scholar
  114. United Nations (1998) WHO, UNICEF, UNU (1998) IDA: Prevention, assessment and control. Report of a joint WHO/UNICEF/UNU consultation, Geneva. World Health Organization, GenevaGoogle Scholar
  115. Uriu-Adams JY, Scherr RE, Lanoue L, Keen CL (2010) Influence of copper on early development: prenatal and postnatal considerations. Biofactors 36(2):136–152Google Scholar
  116. Vallee B, Falchuk KH (1993) The biochemical basis of zinc physiology. Physiol Rev 73:79–118CrossRefGoogle Scholar
  117. Van Wersch JW, Janssens Y, Zandvoort JA (2002) Folic acid, vitamin B(12), and homocysteine in smoking and non-smoking pregnant women. Eur J Obstet Gynecol Reprod Biol 103:18–21CrossRefGoogle Scholar
  118. Walsh T et al (1994) Zinc: health effects and research priorities for the 1990’s. Environ Health Perspect 102:5–46Google Scholar
  119. Wang K, Zhou B, Kuo YM, Zemansky J, Gitschier J (2002) A novel member of a zinc transporter family is defective in acrodermatitis enteropathica. Am J Hum Genet 71:66–73CrossRefGoogle Scholar
  120. Wasantwisut E, Neufeld (2012) Use of nutritional biomarkers in program evaluation in the context of developing countries. J Nutr 142(1):186S–90SGoogle Scholar
  121. Welch RM (1986) Effects of nutrient deficiencies on seed production and quality. Adv Plant Nutr 2:205–247Google Scholar
  122. Welch RM (1996) The optimal breeding strategy is to increase the density of promoter compounds and micronutrient minerals in seeds: caution should be used in reducing anti-nutrients in staple food crops. Micronutr Agric 1:20–22Google Scholar
  123. Welch RM (2008) Linkages between trace elements in food crops and human health. Micronutr Defic Glob Crop Prod 287–309Google Scholar
  124. Welch RM, Graham RD (1999) A new paradigm for world agriculture: meeting human needs: productive, sustainable, nutritious. Field Crop Res 60(1):1–10CrossRefGoogle Scholar
  125. Wissuwa M, Ismail AM, Graham RD (2008) Rice grain zinc concentrationsas affected by genotype, native soil-zinc availability, and zincfertilization. Plant Soil 306:37–48Google Scholar
  126. World Health Organization (1995) http://www.who.int/nut/malnutrition_worldwide.htm Malnutrition Worldwide. World Health Organization, Geneva
  127. The World Health Report 2002: reducing risks, promoting healthy life. GenevaGoogle Scholar
  128. WHO (2009) Trace elements in human nutrition and health. World Health Organization, GenevaGoogle Scholar
  129. WHO (2011) World Health Statistics. World Health Organization, GenevaGoogle Scholar
  130. WHO (2012) The World Health Report 2012, World Health Organization, GenevaGoogle Scholar
  131. Zimmermann B (2011) The role of iodine in human growth and development. Semin Cells Dev Biol 22:645–652CrossRefGoogle Scholar

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© Springer Science+Business Media Dordrecht 2013

Authors and Affiliations

  1. 1.School of Biological SciencesFlinders University of South AustraliaAdelaideAustralia

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