The Coxiella burnetii Parasitophorous Vacuole

  • Eric Ghigo
  • María I. Colombo
  • Robert A. Heinzen
Part of the Advances in Experimental Medicine and Biology book series (volume 984)

Abstract

Coxiella burnetii is a bacterial intracellular parasite of eucaryotic cells that replicates within a membrane-bound compartment, or “parasitophorous vacuole” (PV). With the exception of human macrophages/monocytes, the consensus model of PV trafficking in host cells invokes endolysosomal maturation culminating in lysosome fusion. C. burnetii resists the degradative functions of the vacuole while at the same time exploiting the acidic pH for metabolic activation. While at first glance the mature PV resembles a large phagolysosome, an increasing body of evidence indicates the vacuole is in fact a specialized compartment that is actively modified by the pathogen. Adding to the complexity of PV biogenesis is new data showing vacuole engagement with autophagic and early secretory pathways. In this chapter, we review current knowledge of PV nature and development, and discuss disparate data related to the ultimate maturation state of PV harboring virulent or avirulent C. burnetii lipopolysaccharide phase variants in human mononuclear phagocytes.

Keywords

Macrophage Parasitophorous vacuole Endosome Lysosome Autophagy Integrin Lipopolysaccharide Monocyte Phase variation Secretory pathway 

Notes

Acknowledgements

We thank Dale Howe and Stacy Gilk for critical reading of the manuscript. This research was supported by the CNRS (E. G.), the Agencia Nacional de Promoción Científica y Tecnológica and SECTyP (Universidad Nacional de Cuyo) (M. I. C.) and the Intramural Research Program of the National Institutes of Health, National Institute of Allergy and Infectious Diseases (R. A. H.)

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Eric Ghigo
    • 1
  • María I. Colombo
    • 2
  • Robert A. Heinzen
    • 3
  1. 1.URMITE CNRS UMR 6236 – IRD 3R198, Institut Fédératif de Recherche 48Université de la MéditerranéeMarseilleFrance
  2. 2.Laboratorio de Biología Celular y Molecular, Instituto de Histología y Embriología (IHEM)-CONICET, Facultad de Ciencias MédicasUniversidad Nacional de CuyoMendozaArgentina
  3. 3.Coxiella Pathogenesis Section, Laboratory of Intracellular Parasites, Rocky Mountain LaboratoriesNational Institute of Allergy and Infectious Diseases, National Institutes of HealthHamiltonUSA

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