Use of Recombinant Viruses to Manipulate Neural Stem Cell Gene Expression in the Mouse Brain

  • Konstantin Khodosevich
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 7)


Adult mammalian brain preserves neural stem cells (NSCs) that contribute to postnatal neurogenesis. The last decade has seen a tremendous progress in the identification and analysis of NSCs in the mouse brain. A handful of molecular and cell biology techniques have been applied to confirm the existence and to address the functions of NSCs in the adult brain. Recombinant viruses constitute one of the most powerful and versatile tools for the analysis of NSCs in vivo. This chapter describes major recombinant viruses that are presently available and discusses their applicability to the NSC analysis.


Recombinant Virus Vesicular Stomatitis Virus Equine Infectious Anemia Virus Rostral Migratory Stream Neurogenic Niche 
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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.Department of Clinical Neurobiology/A230German Cancer Research Center (DKFZ)HeidelbergGermany

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