Role of Induced Pluripotent Stem Cells in Regenerative Medicine

  • Wenyan Leong
  • Dong-An Wang
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 7)


Induced pluripotent stem (iPS) technology was first reported by Takahashi and Yamanaka (Cell 126:663–676, 2006) and has since received much attention. These murine iPS cells are similar to embryonic stem cells (ESCs) in many aspects such as gene expression patterns and teratoma formation, except that they originated from somatic cells. Since the pioneer report, the technology has progressed to include many various approaches of reprogramming, such as using viral vectors, plasmids, RNA and proteins. Each approach has its own pros and cons in terms of safety and efficiency, which affect its potential to be translated into the clinical setting. In 2007, two separate groups – Yu et al. (Science 318:1917–1920, 2007) and Takahashi et al. (Cell 131:861–872, 2007) – reported the successful reprogramming of adult human somatic cells into iPS cells, hence sparking hope in developmental biology, pharmacological testing and regenerative medicine. Especially in regenerative medicine, iPS cells are envisaged to be utilized due to their self-renewal and pluripotency – problems of low cell numbers associated with current regenerative approaches can be resolved using iPS cells without the controversy of using ESCs. Here, we discuss the various reprogramming techniques and the myriad of studies on regenerating functional cells and tissues using iPS cells.


Regenerative Medicine Dystrophin Gene Human Artificial Chromosome ATP7B Gene Silk Fibroin Scaffold 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.Division of Bioengineering, School of Chemical and Biomedical EngineeringNanyang Technological UniversitySingaporeSingapore

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