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The Role of Chondrogenic Factors in Differentiation of Bone Marrow Stromal Cells to the Cartilage Lineage

  • Emily M. Florine
  • Alan J. Grodzinsky
Chapter
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 7)

Abstract

Bone marrow stromal cells (BMSCs) are an established cell choice for cartilage repair because they are easily harvested, expanded, and differentiated into a cartilage phenotype characterized by aggrecan and type II collagen production. Transforming growth factor β (TGF-β), insulin-like growth factor 1 (IGF-1), and Dexamethasone (Dex) all influence the process of chondrogenesis. Although difficult challenges remain for optimizing the use of BMSCs for cartilage tissue engineering, in vitro culture systems present an excellent opportunity for studying chondrogenesis and understanding how progenitor cells respond to their biological, chemical, and mechanical microenvironment.

Keywords

Bone Marrow Stromal Cell Cartilage Repair Autologous Chondrocyte Implantation Proteoglycan Synthesis Cartilage Tissue Engineering 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  1. 1.Center for Biomedical EngineeringMassachusetts Institute of TechnologyCambridgeUSA

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