Glycogen Metabolism Regulation in Neurospora crassa

  • Maria C. Bertolini
  • Fernanda Z. Freitas
  • Renato M. de Paula
  • Fernanda B. Cupertino
  • Rodrigo D. Goncalves


Microorganisms accumulate glycogen as carbon and energy reserves to face adverse environmental conditions during growth and development. The processes of glycogen synthesis and degradation share similarities among different microorganisms. However, the regulation of the metabolism as a whole shows differences, likely due to the environmental conditions to which they individually respond. This chapter aims to present some molecular mechanisms that regulate glycogen metabolism in the fungus Neurospora crassa. The availability of its genome sequence (Galagan et al., Nature 422:859–868, 2003) and a collection of mutant strains, each carrying a deletion in a specific ORF, allowed investigation into the role of specific proteins as regulators of glycogen metabolism to begin. Here we present some biochemical and molecular mechanisms that have already been described for this fungus, and additionally, we focused on more recent findings including the molecular basis underlying the metabolism regulation, mainly at transcriptional level.


Heat Shock Neurospora Crassa Glycogen Phosphorylase Glycogen Metabolism Glycogen Accumulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The work in the author’s laboratory was supported by grants and fellowships from FAPESP (Fundação de Amparo à Pesquisa do Estado de São Paulo), CNPq (Conselho Nacional de Desenvolvimento Científico e Tecnológico), and CAPES (Coorde nação de Aperfeiçoamento de Pessoal de Nível Superior).


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Maria C. Bertolini
    • 1
  • Fernanda Z. Freitas
    • 1
  • Renato M. de Paula
    • 2
  • Fernanda B. Cupertino
    • 1
  • Rodrigo D. Goncalves
    • 1
  1. 1.Departamento de Bioquímica e Tecnologia QuímicaInstituto de Química, UNESPAraraquaraBrazil
  2. 2.Nalco CompanySugar LandUSA

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