Abstract
Midkine (MK) and pleotrophin (PTN) are members of a family of heparin-binding growth factors that promotes the proliferation, differentiation, survival, adhesion, migration, and other activities of responding cells, they have become promising molecular targets for the treatment of diseases including malignancy and immune mediated inflammatory diseases. MK is involved in the regulation of organ development and the etiology of many diseases. This chapter focuses on both cell protective and cytokine like effects of MK in different inflammatory conditions at the cellular/systemic levels.
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Funding: This chapter contains data from studies supported by TUBITAK-BMBF (SBAG104S329, SBAG108S262).
Conflict of interest: We certify that there is no conflict of interest with any financial organization regarding the material discussed in the manuscript.
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Yazıhan, N., Kocak, M.K., Akcıl, E. (2012). Midkine in Inflammation and Inflammatory Diseases. In: Ergüven, M., Muramatsu, T., Bilir, A. (eds) Midkine: From Embryogenesis to Pathogenesis and Therapy. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4234-5_7
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DOI: https://doi.org/10.1007/978-94-007-4234-5_7
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