Abstract
There is growing biomedical interest in survivin as a diagnostic and prognostic factor in human neoplasms. The present work assessed survivin expression in retinoblastoma. Survivin was quantitatively measured in 82 aqueous humor and serum samples from 41 children with retinoblastoma and nonmalignant ophthalmic diseases. After treatment, 12 serum samples from retinoblastoma patients were included. Survivin levels were higher in aqueous humor and serum of retinoblastoma patients than the controls (P < 0.05). In aqueous, it was significantly correlated with the tumor stage and optic nerve affection. The best cutoff values for survivin in aqueous and serum that differentiate between retinoblastoma and nonmalignant ophthalmic diseases were 25.2 pg/mg protein and 12.9 pg/mL, respectively. The sensitivity and specificity were 100% and 90% in serum and 94% and 48% in aqueous, respectively. Serum survivin has decreased significantly after treatment. Measurement of survivin protein might have a great diagnostic and prognostic potential in retinoblastoma.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Abramson DH (2005) Retinoblastoma in the 20th century: past success and future challenges the Weisenfeld lecture. Invest Ophthalmol Vis Sci 46:2683–2691
Altieri DC (2001) The molecular basis and potential role of survivin in cancer diagnosis and therapy. Trends Mol Med 7:542–547
Ambrosini G, Adida C, Altieri DC (1997) A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat Med 3:917–921
Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248–254
Cao M, Yie SM, Wu SM, Chen S, Lou B, He X, Ye SR, Xie K, Rao L, Gao E, Ye NY (2009) Detection of survivin-expressing circulating cancer cells in the peripheral blood of patients with esophageal squamous cell carcinoma and its clinical significance. Clin Exp Metastasis 26:751–758
Chantalat L, Skoufias DA, Kleman JP, Jung B, Dideberg O, Margolis RL (2000) Crystal structure of human survivin reveals a bow tie-shaped dimer with two unusual alpha-helical extensions. Mol Cell 6:183–189
Crook NE, Clem RJ, Miller LK (1993) An apoptosis-inhibiting baculoviruses gene with a zinc finger-like motif. J Virol 67:2168–2174
Gianani R, Jarboe E, Orlicky D, Frost M, Bobak J, Lehner R, Shroyer KR (2001) Expression of survivin in normal, hyperplastic, and neoplastic colonic mucosa. Hum Pathol 32:119–125
Goksel G, Taneli F, Uslu R, Ulman C, Dinc G, Coskun T, Kandiloglu AR (2007) Serum her-2/neu and survivin levels and their relationship to histological parameters in early-stage breast cancer. J Int Med Res 35:165–172
Guney N, Soydine HO, Derin D, Tas F, Camlica H, Duranyildiz D, Yasasever V, Topuz E (2006) Serum and urine survivin levels in breast cancer. Med Oncol 23:335–339
Harbour JW, Dean DC (2000) Rb function in cell-cycle regulation and apoptosis. Nat Cell Biol 2:65–67
Hoffmann AC, Warnecke-Eberz U, Luebke T, Prenzel K, Metzger R, Heitmann M, Neiss S, Vallbohmer D, Hoelscher AH, Schneider PM (2007) Survivin mRNA in peripheral blood is frequently detected and significantly decreased following resection of gastrointestinal cancers. J Surg Oncol 95:51–54
Jiang LB, Liu XQ, Li B, He XJ, Jin YL, Li LQ, Gao F, Wang NL (2008) Heat shock proteins and survivin: relationship and effects on proliferation index of retinoblastoma cells. Histol Histopathol 23:827–831
Johnson ME, Howerth EW (2004) Survivin: a bifunctional inhibitor of apoptosis protein. Vet Pathol 41:599–607
Laurie NA, Donovan SL, Shih CS, Zhang J, Mills N, Fuller C, Teunisse A, Lam S, Ramos Y, Mohan A, Johnson D, Wilson M, Rodriguez-Galindo C, Quarto M, Francoz S, Mendrysa SM, Guy RK, Marine JC, Jochemsen AG, Dyer MA (2006) Inactivation of the p53 pathway in retinoblastoma. Nature 444:61–66
Li YH, Hu CF, Shao Q, Huang MY, Hou JH, Xie D, Zeng YX, Shao JY (2008) Elevated expressions of survivin and VEGF protein are strong independent predictors of survival in advanced nasopharyngeal carcinoma. J Transl Med 6:1
Lin P, O’Brien JM (2009) Frontiers in the management of retinoblastoma. Am J Ophthalmol 148:192–198
Nakayama K, Kamihira S (2002) Survivin an important determinant for prognosis in adult T-cell leukemia: a novel biomarker in practical hemato-oncology. Leuk Lymphoma 43:2249–2255
Poulaki V, Mitsiades CS, Joussen AM, Lappas A, Kirchhof B, Mitsiades N (2002) Constitutive nuclear factor-kappaB activity is crucial for human retinoblastoma cell viability. Am J Pathol 161:2229–2240
Rousseau A, Kujas M, Bergemer-Fouquet AM, van Effenterre R, Hauw JJ (2006) Survivin expression in ganglioglioma. J Neurooncol 77:153–159
Sasaki T, Lopes MB, Hankins GR, Helm GA (2002) Expression of survivin, an inhibitor of apoptosis protein, in tumors of the nervous system. Acta Neuropathol 104:105–109
Seregard S, Lundell G, Svedberg H, Kivelä T (2004) Incidence of retinoblastoma from 1958 to 1998 in Northern Europe: advantages of birth cohort analysis. Ophthalmology 111:1228–1232
Vogel F (1979) Genetics of retinoblastoma. Hum Genet 52:1–54
Wang ZN, Xu HM, Jiang L, Zhou X, Lu C, Zhang X (2004) Expression of survivin mRNA in peritoneal lavage fluid from patients with gastric carcinoma. Chin Med J 117:1210–1217
Wang J, Huang C, Wei XY, Qi DL, Gong LQ, Mu HY, Yao Q, Li K (2008) Changes of activated circulating endothelial cells and survivin in patients with non-small cell lung cancer after antiangiogenesis therapy. Chin Med J 121:2234–2240
Wu YK, Chen KT, Kuo YB, Huang YS, Chan EC (2009) Quantitative detection of survivin in malignant pleural effusion for the diagnosis and prognosis of lung cancer. Cancer Lett 273:331–335
Xiang XJ, He YJ, Li YH, Huang H, Xu F (2006) Clinical significance of survivin expression in peripheral T-cell lymphoma. Ai Zheng 25:758–761
Xu Y, Fang F, Ludewig G, Jones G, Jones D (2004) A mutation found in the promoter region of the human survivin gene is correlated to overexpression of survivin in cancer cells. DNA Cell Biol 23:527–537
Zhao J, Tenev T, Martins LM, Downward J, Lemoine NR (2000) The ubiquitin-proteasome pathway regulates survivin degradation in a cell cycle-dependent manner. J Cell Sci 113:4363–4371
Ziaee SA, Moula SJ, Hosseini Moghaddam SM, Eskandar-Shiri D (2006) Diagnosis of bladder cancer by urine survivin, an inhibitor of apoptosis: a preliminary report. Urol J 3:150–153
Acknowledgment
We greatly appreciate the valuable and limitless cooperation of all patients included in the study and their parents.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer Science+Business Media Dordrecht
About this chapter
Cite this chapter
Shehata, H., Ghalia, A.A., Elsayed, E. (2012). Role of Survivin in Retinoblastoma: Diagnosis and Prognosis. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 8. Tumors of the Central Nervous System, vol 8. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4213-0_12
Download citation
DOI: https://doi.org/10.1007/978-94-007-4213-0_12
Published:
Publisher Name: Springer, Dordrecht
Print ISBN: 978-94-007-4212-3
Online ISBN: 978-94-007-4213-0
eBook Packages: MedicineMedicine (R0)