Abstract
Migration is a key cellular process, involved during morphogenetic movements as well as in the adult where it participates in immune cell trafficking, wound healing or tumour invasion. As they migrate, cells interact with a microenvironment composed of extracellular matrix and neighbouring cells. Cell–cell adhesions ensure tissue integrity while they allow migration of single or grouped cells within this tissue. Cadherin and nectin-based adherens junctions are key players in intercellular interactions. They are used as adhesive complexes whose mechanical properties improve cell coordination during collective migration and promote cell motility on cadherin substrates. In addition, adherens junctions transduce signals that actively participate in the control of directed cell migration, by providing polarity cues and also participating in contact inhibition of motility.
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Acknowledgments
I thank Florent Peglion for his immunofluorescence images shown in the figures. This work was supported by the Agence Nationale pour la recherche, the Institut Pasteur, Association pour la Recherche sur le Cancer, La Ligue contre le Cancer, and l’Institut National du Cancer. S.E.M. is a member of the EMBO YIP.
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Etienne-Manneville, S. (2012). Adherens Junctions During Cell Migration. In: Harris, T. (eds) Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease. Subcellular Biochemistry, vol 60. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4186-7_10
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