In-Silico Models as a Tool for the Design of Specific Treatments: Applications in Bone Regeneration

  • Esther Reina-Romo
  • María José Gómez-Benito
  • Libardo Andrés González-Torres
  • Jaime Domínguez
  • José Manuel García-Aznar
Part of the Lecture Notes in Computational Vision and Biomechanics book series (LNCVB, volume 1)


Numerous pathologies related to bone regeneration such as bone healing or distraction osteogenesis are focus of intense research nowadays since there are many cues not well understood yet. Intense activity is performed in both experimental and computational fields. However, in silico models may play a relevant role since computer simulations allow to consider and control factors that cannot be easily controlled or measured in experimental tests. In addition, experiments can be time-consuming, expensive and with a high difficulty to control all the parameters. This review addresses some of the main problems of in-silico models and focus on bone healing and distraction osteogenesis as mechanical based pathologies extensively investigated in the last decades.


Fracture Healing Bone Regeneration Distraction Osteogenesis Endochondral Ossification Fracture Callus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The authors gratefully acknowledge the research support of the project part financed by the European Union (European Regional Development Fund) through the grant DPI 2009-14115-C03-01.


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Esther Reina-Romo
    • 1
  • María José Gómez-Benito
    • 2
  • Libardo Andrés González-Torres
    • 2
  • Jaime Domínguez
    • 1
  • José Manuel García-Aznar
    • 2
  1. 1.Department of Mechanical EngineeringUniversity of SevilleSevilleSpain
  2. 2.Aragon Institute of Engineering Research (I3A)University of ZaragozaZaragozaSpain

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