Rubus occidentalis

  • T. K. Lim


Black Raspberry is indigenous to East and central North America: New Brunswick to Minnesota, south to Georgia, west to Nebraska and Colorado.


Ellagic Acid Oxygen Radical Absorbance Capacity Black Raspberry Berry Fruit Syrian Hamster Embryo 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Selected References

  1. Bailey LH (1976) Hortus Third. A concise dictionary of plants cultivated in the United States and Canada. Liberty Hyde Bailey Hortorium/Cornell University/Wiley, New York, 1312 ppGoogle Scholar
  2. Bi X, Fang W, Wang LS, Stoner GD, Yang W (2010) Black raspberries inhibit intestinal tumorigenesis in apc1638  +/− and Muc2  −/− mouse models of colorectal cancer. Cancer Prev Res (Phila) 3(11):1443–1450CrossRefGoogle Scholar
  3. Casto BC, Kresty LA, Kraly CL, Pearl DK, Knobloch TJ, Schut HA, Stoner GD, Mallery SR, Weghorst CM (2002) Chemoprevention of oral cancer by black raspberries. Anticancer Res 22(6C):4005–4015PubMedGoogle Scholar
  4. Chen T, Hwang H, Rose ME, Nines RG, Stoner GD (2006a) Chemopreventive properties of black raspberries in N-nitrosomethylbenzylamine-induced rat esophageal tumorigenesis: down-regulation of cyclooxygenase-2, inducible nitric oxide synthase, and c-Jun. Cancer Res 66(5):2853–2859PubMedCrossRefGoogle Scholar
  5. Chen T, Rose ME, Hwang H, Nines RG, Stoner GD (2006b) Black raspberries inhibit N-nitro­so­methyl­benzylamine (NMBA)-induced angiogenesis in rat esophagus parallel to the suppression of COX-2 and iNOS. Carcinogenesis 27(11):2301–2307PubMedCrossRefGoogle Scholar
  6. Facciola S (1990) Cornucopia. A source book of edible plants. Kampong Publ, Vista, 677 ppGoogle Scholar
  7. Grae I (1974) Nature’s colors – dyes from plants. MacMillan Publishing Co, New YorkGoogle Scholar
  8. Hákkinen S, Heinonen M, Kárenlampi S, Mykkánen H, Ruuskanen J, Törrönen R (1999) Screening of selected flavonoids and phenolic acids in 19 berries. Food Res Int 32:345–353CrossRefGoogle Scholar
  9. Han C, Ding H, Casto B, Stoner GD, D’Ambrosio SM (2005) Inhibition of the growth of premalignant and malignant human oral cell lines by extracts and components of black raspberries. Nutr Cancer 51(2):207–217PubMedCrossRefGoogle Scholar
  10. Hecht SS, Huang C, Stoner GD, Li J, Kenney PM, Sturla SJ, Carmella SG (2006) Identification of cyanidin glycosides as constituents of freeze-dried black raspberries which inhibit anti-benzo[a]pyrene-7,8-diol-9,10-epoxide induced NFkappaB and AP-1 activity. Carcinogenesis 27(8):1617–1626PubMedCrossRefGoogle Scholar
  11. Huang C, HuangY Li J, Hu W, Aziz R, Tang MS, Sun N, Cassady J, Stoner GD (2002) Inhibition of benzo(a)pyrene diol-epoxide-induced transactivation of activated protein 1 and nuclear factor kappaB by black raspberry extracts. Cancer Res 62(23):6857–6863PubMedGoogle Scholar
  12. Huang C, Li J, Song L, Zhang D, Tong Q, Ding M, Bowman L, Aziz R, Stoner GD (2006) Black ­raspberry extracts inhibit benzo(a)pyrene diol-epoxide-induced activator protein 1 activation and VEGF transcription by targeting the phosphotidylinositol 3-kinase/Akt pathway. Cancer Res 66(1):581–587PubMedCrossRefGoogle Scholar
  13. Jennings DL (1988) Raspberries and blackberries: their breeding, disease and growth. Academic, London, 230 ppGoogle Scholar
  14. Johnson JL, Bomser JA, Scheerens JC, Giusti MM (2011) Effect of black raspberry (Rubus occidentalis L.) extract variation conditioned by on colon cancer cell proliferation. J Agric Food Chem 59(5):1638–1645PubMedCrossRefGoogle Scholar
  15. Kresty LA, Frankel WL, Hammond CD, Baird ME, Mele JM, Stoner GD, Fromkes JJ (2006) Transitioning from preclinical to clinical chemopreventive assessments of lyophilized black raspberries: interim results show berries modulate markers of oxidative stress in Barrett’s esophagus patients. Nutr Cancer 54:148–156PubMedCrossRefGoogle Scholar
  16. Kresty LA, Morse MA, Morgan C, Carlton PS, Lu J, Gupta A, Blackwood M, Stoner GD (2001) Chemoprevention of esophageal tumorigenesis by dietary administration of lyophilized black raspberries. Cancer Res 61:6112–6119PubMedGoogle Scholar
  17. Kunkel G (1984) Plants for human consumption. An annotated checklist of the edible phanerogams and ferns. Koeltz Scientific Books, KoenigsteinGoogle Scholar
  18. Landete JM (2011) Ellagitannins, ellagic acid and their derived metabolites: a review about source, metabolism, functions and health. Food Res Int 44(5):1150–1160CrossRefGoogle Scholar
  19. Li J, Zhang D, Stoner GD, Huang C (2008) Differential effects of black raspberry and strawberry extracts on BaPDE-induced activation of transcription factors and their target genes. Mol Carcinog 47(4):286–294PubMedCrossRefGoogle Scholar
  20. Ling Y, Ren C, Mallery SR, Ugalde CM, Pei P, Saradhi UV, Stoner GD, Chan KK, Liu Z (2009) A rapid and sensitive LC-MS/MS method for quantification of four anthocyanins and its application in a clinical pharmacology study of a bioadhesive black raspberry gel. J Chromatogr B Analyt Technol Biomed Life Sci 877(31):4027–4034PubMedCrossRefGoogle Scholar
  21. Liu Z, Schwimer J, Liu D, Greenway FL, Anthony CT, Woltering EA (2005) Black raspberry extract and fractions contain angiogenesis inhibitors. J Agric Food Chem 53(10):3909–3915PubMedCrossRefGoogle Scholar
  22. Mallery SR, Budendorf DE, Larsen MP, Pei P, Tong M, Holpuch AS, Larsen PE, Stoner GD, Fields HW, Chan KK, Ling Y, Liu Z (2011) Effects of human oral mucosal tissue, saliva, and oral microflora on intraoral metabolism and bioactivation of black raspberry anthocyanins. Cancer Prev Res (Phila) 4(8):1209–1221CrossRefGoogle Scholar
  23. Mallery SR, Stoner GD, Larsen PE, Fields HW, Rodrigo KA, Schwartz SJ, Tian Q, Dai J, Mumper RJ (2007) Formulation and in-vitro and in-vivo evaluation of a mucoadhesive gel containing freeze dried black raspberries: implications for oral cancer chemoprevention. Pharm Res 24(4):728–737PubMedCrossRefGoogle Scholar
  24. Mallery SR, Zwick JC, Pei P, Tong M, Larsen PF, Shumway BS, Lu B, Fileds HW, Mumper RJ, Stoner GD (2008) Application of a bioadhesive black raspberry gel modulates gene expression and reduces cyclooxygenase 2 protein in human premalignant oral lesions. Cancer Res 68(12):4945–4957PubMedCrossRefGoogle Scholar
  25. Moerman D (1998) Native American ethnobotany. Timber Press, Oregon, 927 ppGoogle Scholar
  26. Montrose DC, Horelik NA, Madigan JP, Stoner GD, Wang LS, Bruno RS, Park HJ, Giardina C, Rosenberg DW (2011) Anti-inflammatory effects of freeze-dried black raspberry powder in ulcerative colitis. Carcinogenesis 32(3):343–350PubMedCrossRefGoogle Scholar
  27. Parry J, Su L, Moore J, Cheng Z, Luther M, Rao JN, Wang JY, Yu LL (2006) Chemical compositions, antioxidant capacities, and antiproliferative activities of selected fruit seed flours. J Agric Food Chem 54(11):3773–3778PubMedCrossRefGoogle Scholar
  28. Parry J, Yu L (2004) Fatty acid content and antioxidant properties of cold-pressed black raspberry seed oil and meal. J Food Sci 69(3):FCT189–FCT193CrossRefGoogle Scholar
  29. Reen RK, Nines R, Stoner GD (2006) Modulation of N-nitrosomethylbenzylamine metabolism by black raspberries in the esophagus and liver of Fischer 344 rats. Nutr Cancer 54(1):47–57PubMedCrossRefGoogle Scholar
  30. Rodrigo KA, Rawal Y, Renner RJ, Schwartz SJ, Tian Q, Larsen PE, Mallery SR (2006) Suppression of the tumorigenic phenotype in human oral squamous cell carcinoma cells by an ethanol extract derived from freeze-dried black raspberries. Nutr Cancer 54(1):58–68PubMedCrossRefGoogle Scholar
  31. Seeram NP (2006) Berries. In: Heber D, Blackburn G, Go V, Milner J (eds) Nutritional oncology. Elsevier, Inc, Amsterdam, pp 615–628, Chapter 37CrossRefGoogle Scholar
  32. Seeram NP, Adams LS, Zhang Y, Lee R, Sand D, Scheuller HS, Heber D (2006) Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. J Agric Food Chem 54(25):9329–9339PubMedCrossRefGoogle Scholar
  33. Stoner GD, Chen T, Kresty LA, Aziz RM, Reinemann T, Nines R (2006) Protection against esophageal cancer in rodents with lyophilized berries: potential mechanisms. Nutr Cancer 54(1):33–46PubMedCrossRefGoogle Scholar
  34. Stoner GD, Dombkowski AA, Reen RK, Cukovic D, Salagrama S, Wang LS, Lechner JF (2008a) Carcinogen-altered genes in rat esophagus positively modulated to normal levels of expression by both black raspberries and phenylethyl isothiocyanate. Cancer Res 68(15):6460–6467PubMedCrossRefGoogle Scholar
  35. Stoner GD, Sardo C, Apseloff G, Mullet D, Wargo W, Pound V, Singh A, Sanders J, Aziz R, Casto B, Sun XL (2005) Pharmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries daily for 7 days. J Clin Pharmacol 45:1153–1164PubMedCrossRefGoogle Scholar
  36. Stoner GD, Wang LS, Casto BC (2008b) Laboratory and clinical studies of cancer chemoprevention by antioxidants in berries. Carcinogenesis 29(9):1665–1674PubMedCrossRefGoogle Scholar
  37. Stoner GD, Wang LS, Seguin C, Rocha C, Stoner K, Chiu S, Kinghorn AD (2010) Multiple berry types prevent N-nitrosomethylbenzylamine-induced esophageal cancer in rats. Pharm Res 27(6):1138–1145PubMedCrossRefGoogle Scholar
  38. Stoner GD, Wang LS, Zikri N, Chen T, Hecht SS, Huang C, Sardo C, Lechner JF (2007) Cancer prevention with freeze-dried berries and berry components. Semin Cancer Biol 17(5):403–410PubMedCrossRefGoogle Scholar
  39. Tulio AZ Jr, Reese RN, Wyzgoski FJ, Rinaldi PL, Fu R, Scheerens JC, Miller AR (2008) Cyanidin 3-rutinoside and cyanidin 3-xylosylrutinoside as primary phenolic antioxidants in black raspberry. J Agric Food Chem 56(6):1880–1888PubMedCrossRefGoogle Scholar
  40. U.S. Department of Agriculture, Agricultural Research Service (USDA) (2011) USDA National Nutrient Database for Standard Reference, Release 24. Nutrient Data Laboratory Home Page,
  41. Wada L, Ou B (2002) Antioxidant activity and phenolic content of Oregon caneberries. J Agric Food Chem 50(12):3495–3500PubMedCrossRefGoogle Scholar
  42. Wang LS, Arnold M, Huang YW, Sardo C, Seguin C, Martin E, Huang TH, Riedl K, Schwartz S, Frankel W, Pearl D, Xu Y, Winston J 3rd, Yang GY, Stoner G (2011a) Modulation of genetic and epigenetic biomarkers of colorectal cancer in humans by black raspberries: a phase I pilot study. Clin Cancer Res 17(3):598–610PubMedCrossRefGoogle Scholar
  43. Wang LS, Dombkowski AA, Seguin C, Rocha C, Cukovic D, Mukundan A, Henry C, Stoner GD (2011b) Mechanistic basis for the chemopreventive effects of black raspberries at a late stage of rat esophageal carcinogenesis. Mol Carcinog 50(4):291–300PubMedCrossRefGoogle Scholar
  44. Wang LS, Hecht S, Carmella S, Seguin C, Rocha C, Yu N, Stoner K, Chiu S, Stoner G (2010) Berry ellagitannins may not be sufficient for prevention of tumors in the rodent esophagus. J Agric Food Chem 58(7):3992–3995PubMedCrossRefGoogle Scholar
  45. Wang LS, Hecht SS, Carmella SG, Yu N, Larue B, Henry C, McIntyre C, Rocha C, Lechner JF, Stoner GD (2009) Anthocyanins in black raspberries prevent esophageal tumors in rats. Cancer Prev Res (Phila) 2(1):84–93CrossRefGoogle Scholar
  46. Wang SY, Lin HS (2000) Antioxidant activity in fruits and leaves of blackberry, raspberry, and strawberry varies with cultivar and developmental stage. J Agric Food Chem 48(2):140–146PubMedCrossRefGoogle Scholar
  47. Xue H, Aziz RM, Sun N, Cassady JM, Kamendulis LM, Xu Y, Stoner GD, Klaunig JE (2001) Inhibition of cellular transformation by berry extracts. Carcinogenesis 22(2):351–356PubMedCrossRefGoogle Scholar
  48. Zhang Z, Knobloch TJ, Seamon LG, Stoner GD, Cohn DE, Paskett ED, Fowler JM, Weghorst CM (2011) A black raspberry extract inhibits proliferation and regulates apoptosis in cervical cancer cells. Gynecol Oncol 123(2):401–406PubMedCrossRefGoogle Scholar
  49. Zikri NN, Riedl KM, Wang LS, Lechner J, Schwartz SJ, Stoner GD (2009) Black raspberry components inhibit proliferation, induce apoptosis, and modulate gene expression in rat esophageal epithelial cells. Nutr Cancer 61(6):816–826PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.CanberraAustralia

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