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Peripheral Blood Monocytes Can Be Induced to Acquire Stem Cell-Like Properties

  • Hendrik Ungefroren
  • Ayman Hyder
  • Hebke Hinz
  • Norbert Reiling
  • Evelin Grage-Griebenow
  • Maren Schulze
  • Sabrina Ehnert
  • Andreas K. Nüssler
  • Fred Fändrich
Chapter
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 6)

Abstract

Adult stem or programmable cells hold great promise in diseases in which damaged or non-functional cells need to be replaced. We have recently demonstrated that peripheral blood monocytes can be differentiated in vitro into cells whose phenotypes resemble specialized cell types like hepatocytes and pancreatic beta cells. During phenotypic conversion the monocytes downregulate monocyte/macrophage differentiation markers being indicative of partial dedifferentiation and are partially reprogrammed to acquire a state of plasticity along with expression of various markers of pluripotency. These cells were termed “programmable cells of monocytic origin” (PCMOs). Current efforts focus on establishing culture conditions that increase both the plasticity and proliferation potential of PCMOs in order to be able to generate large amounts of blood-derived cells suitable for both autologous and allogeneic therapies.

Keywords

Somatic Cell Nuclear Transfer Peripheral Blood Monocyte Autologous Serum Pluripotency Gene Stem Cell Renewal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Hendrik Ungefroren
    • 1
  • Ayman Hyder
    • 2
  • Hebke Hinz
    • 2
  • Norbert Reiling
    • 3
  • Evelin Grage-Griebenow
    • 4
  • Maren Schulze
    • 5
  • Sabrina Ehnert
    • 6
  • Andreas K. Nüssler
    • 6
  • Fred Fändrich
    • 2
  1. 1.Abtlg. Hämatologie/OnkologieMedizinische Klinik I –ZKLübeckGermany
  2. 2.Department of Applied Cellular MedicineUniversity Hospital Schleswig-HolsteinKielGermany
  3. 3.Division of Microbial Interface Biology, Research Center BorstelLeibniz Center for Medicine and BiosciencesBorstelGermany
  4. 4.Department of Internal Medicine I, Laboratory of Molecular Gastroenterology & HepatologyUniversity Hospital Schleswig HolsteinKielGermany
  5. 5.Clinic for General and Thoracic SurgeryUniversity Hospital Schleswig-HolsteinKielGermany
  6. 6.BG Trauma ClinicEberhard-Karls UniversityTübingenGermany

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