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Mouse Bone Marrow Derived Mesenchymal Stem Cells

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Stem Cells and Cancer Stem Cells, Volume 6

Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 6))

Abstract

There is a general belief that adult stem cells are an essential aspect of maintaining tissue health as we age and undergo wound healing, but the mechanisms by which adult stem cells contribute to these processes are poorly understood. One of the more highly investigated adult stem cell populations has been the bone marrow derived mesenchymal stem cell (BMSC). The rare presence of BMSCs within the bone marrow has made it a challenge to understand how this adult stem cell population naturally functions in vivo. While human BMSC research has direct therapeutic application, we believe murine animal models have an important role to play in understanding mechanisms of BMSC biology that are likely to influence how BMSCs are therapeutically used. In this chapter, we discuss the current beliefs in the field with regard to the therapeutic benefit of BMSCs and how we define BMSCs. We also include detailed information on mouse BMSCs and methods that we have developed over the past few years to isolate, identify, and work with mouse BMSCs.

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Authors and Affiliations

  1. Department of Reconstructive Sciences, School of Dental Medicine, Academic Research Building, L7007, MC3705, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, CT, 06030, USA

    Sara Strecker, Yaling Liu, Liping Wang, David Rowe & Peter Maye

Authors
  1. Sara Strecker
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  2. Yaling Liu
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  3. Liping Wang
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  4. David Rowe
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  5. Peter Maye
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Corresponding author

Correspondence to Peter Maye .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Strecker, S., Liu, Y., Wang, L., Rowe, D., Maye, P. (2012). Mouse Bone Marrow Derived Mesenchymal Stem Cells. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 6. Stem Cells and Cancer Stem Cells, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2993-3_20

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