Pediatric Cancer Survivors: Neurocognitive Late Effects

  • Sarah Hile
  • Erica Montague
  • Bonnie Carlson-Green
  • Paul Colte
  • Leanne Embry
  • Robert D. Annett
Part of the Pediatric Cancer book series (PECA, volume 2)


Neurocognitive deficits are a common late effect experienced by pediatric cancer survivors and can manifest across a variety of domains including: attention and concentration, executive functioning, processing speed, psychomotor skills, verbal memory, visuospatial skills, and language (Moore J, Pediatr Psychol 30:51–63, 2005). Deficits have also been found to manifest across the broader domains of global intellectual functioning and academic performance. These deficits, however, seem to be limited to the specific diagnoses of leukemia and brain tumors. This is largely due to the aggressive CNS-directed treatments, as they induce inalterable structural damage to the brain, which has been linked back to observable deficits in neurocognitive functioning. Preliminary research also indicates that neurocognitive deficits can have serious implications for survivors’ overall functional capabilities as well as their general quality of life. As such, a variety of interventions have begun to be developed in order to address these issues. However, research surrounding these two areas is still in its infancy. Future research needs to address how neurocognitive late effects interfere with greater functional capabilities and general quality of life as well as how interventions can help combat these problems.


Cancer Survivor Acute Lymphoblastic Leukemia Cranial Radiation Therapy Childhood Cancer Survivor Pediatric Brain Tumor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media Dordrecht 2012

Authors and Affiliations

  • Sarah Hile
    • 1
  • Erica Montague
    • 1
  • Bonnie Carlson-Green
    • 2
  • Paul Colte
    • 3
  • Leanne Embry
    • 4
  • Robert D. Annett
    • 5
  1. 1.Psychology DepartmentUniversity of New MexicoAlbuquerqueUSA
  2. 2.Children’s Hospitals and Clinics of Minnesota, Psychology ServicesSt. PaulUSA
  3. 3.Division of Hematology/Oncology/BMTPrimary Children’s Medical CenterSalt Lake CityUSA
  4. 4.Pediatric Hematology/OncologyUniversity of Texas Health Science Center at San AntonioSan AntonioUSA
  5. 5.Department of Pediatrics and PsychologyUniversity of New Mexico Health Sciences CenterAlbuquerqueUSA

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