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γδ T Cells, Tea and Cancer

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Nutrition, Diet and Cancer

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Abstract

Environmental factors play an important role in the development of cancer. Tea, one of the most popular beverages in the world, has shown to have anti-cancer effects as well as have protective effects against cancer development. Recent studies have shown that components present in tea could activate the immune system, particularly γδ T cells, which is an important component of both innate and adaptive immune system. As a first line of defense against tumors, the activation of immune system is important to provide necessary preventive measures against tumor. In this chapter, we focus on the mechanism of γδ T cell-mediated recognition of antigens, and delineate the mechanisms, by which tea product can activate γδ T cells to facilitate cancer prevention activities.

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Acknowledgements

This work was supported in part by National Institutes of Health grants, K01 AR054114 (NIAMS), SBIR R44 HL092706-01 (NHLBI), R21 CA143787 (NCI) and The Ohio State University start-up fund. The funders had no role in study design, data collection and analysis, decision to publish or preparation of the manuscript.

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  1. Cardiovascular Stem Cell Research Laboratory, The Dorothy M. Davis Heart and Lung Research Institute, The Ohio State University Medical Center, 460 W. 12th Avenue, BRT 382, Columbus, OH, 43210, USA

    Jingwei Lu, Vincent J. Pompili & Hiranmoy Das

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  1. Jingwei Lu
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  2. Vincent J. Pompili
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Correspondence to Hiranmoy Das .

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  1. , Pathology and Laboratory Medicine, University of Kansas Medical Center, Rainbow Blvd 3901, Kansas City, 66160, Kansas, USA

    Sharmila Shankar

  2. , Pharmacology and Toxicology, University of Kansas Medical Center, Rainbow Blvd 3901, Kansas City, 66160, Kansas, USA

    Rakesh K. Srivastava

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Lu, J., Pompili, V.J., Das, H. (2012). γδ T Cells, Tea and Cancer. In: Shankar, S., Srivastava, R. (eds) Nutrition, Diet and Cancer. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2923-0_8

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