Abstract
Cardiovascular disease is the leading cause of mortality and morbidity all over the world. Current treatments in cardiovascular disease do not prevent the cell loss and have no contribution to regeneration, although these therapies provided an improvement in the survival. Cardiac repair by stem cells promises regenerating damaged myocardium by reconstructing the injured heart from its component parts. Up to date, variety of stem cells including BM mononuclear, adipocyte progenitor cells, fibroblasts, smooth and strait muscle cells, circulating progenitor cells, embryonic stem cells, cord blood cells etc., have been used for cardiac repair experimentally and some at clinically. There is no consensus which cell should be use for cardiac repair. We strongly suggest that vascular wall cells seem to be a good candidate for cardiomyoplasty.
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References
Annarosa L, Kajstura J, Anversa P (2005) Cardiac stem cells and mechanisms of myocardial regeneration. Physiol Rev 85:1373ā1416
Anversa P, Kajstura J (1998) Ventricular myocytes are not terminally differentiated in the adult mammalian heart. Circ Res 83:1ā14
Armulik A, Abramsson A, Betsholtz C (2005) Endothelial/pericyte interactions. Circ Res 97:512ā523
Becker RO, Chapin S, Sherry R (1974) Regeneration of the ventricular myocardium in amphibians. Nature 248:145ā147
Bergmann O, Bhardwaj RD, Bernard S, Zdunek S, BarnabĆ©-Heider F, Walsh S, Zupicich J, Alkass K, Buchholz BA, Druid H, Jovinge S, FrisĆ©n J (2009) Evidence for cardiomyocyte renewal in humans. Science 324(5923):98ā102
Chamley-Campbell J, Campbell GR, Ross R (1979) The smooth muscle cell in culture. Physiol Rev 59(1):1ā61
Duff SE, Li C, Garland JM, Kumar S (2003) CD105 is important for angiogenesis: evidence and potential applications. FASEB J 17:984ā992
Gersh BJ, Simari RD, Behfar A, Terzic CM, Terzic A (2009) Cardiac cell repair therapy: a clinical perspective. Mayo Clin Proc 84:876ā892
Hao H, Gabbiani G, Bochaton-Piallat ML (2003) Arterial smooth muscle cell heterogeneity: implications for atherosclerosis and restenosis development. Arterioscler Thromb Vasc Biol 23(9):1510ā1520
Heldman AW, Zambrano JP, Hare JM (2011) Cell therapy for heart disease where are we in 2011? J Am Coll Cardiol 57:4
Hu Y, Zhang Z, Torsney E, Afzal AR, Davison F, Metzler B, Xu Q (2004) Abundant progenitor cells in the adventitia contribute to atherosclerosis of vein grafts in ApoE-deficient mice. J Clin Invest 113:1258ā1265
Ingram DA, Mead LE, Moore DB, Woodard W, Fenoglio A, Yoder MC (2005) Vessel wallāderived endothelial cells rapidly proliferate because they contain a complete hierarchy of endothelial progenitor cells. Blood 105(7):2783ā2786
Juchem G, Weiss DR, Gansera B, Kemkes BM, Mueller-Hoecker J, Nees S (2010) Pericytes in the macrovascular intima: possible physiological and pathogenetic impact. Am J Physiol Heart Circ Physiol 298(3):H754āH770
Kajstura J, Leri A, Finato N, Di Loreto C, Beltrami CA, Anversa P (1998) Myocyte proliferation in end-stage cardiac failure in humans. Proc Natl Acad Sci USA 95:8801ā8805
Kovacic JC, Boehm M (2009) Resident vascular progenitor cells: an emerging role for non-terminally differentiated vessel-resident cells in vascular biology. Stem Cell Res 2(1):2ā15
Laflamme MA, Myerson D, Saffitz JE, Murry CE (2002) Evidence for cardiomyocyte repopulation by extracardiac progenitors in transplanted human hearts. Circ Res 90:634ā640
Li RK, Jia ZQ, Weisel RD, Merante F, Mickle DA (1999) Smooth muscle cell transplantation into myocardial scar tissue improves heart function. J Mol Cell Cardiol 31:513ā522
Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ (2006) Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 367:1747ā1757
Lyngbaek S, Schneider M, Hansen JL, Sheikh SP (2007) Cardiac regeneration by resident stem and progenitor cells in the adult heart. Basic Res Cardiol 102:101ā114
Martin-Rendon E, Brunskill SJ, Hyde CJ, Stanworth SJ, Mathur A, Watt SM (2008) Autologous bone marrow stem cells to treat acute myocardial infarction: a systematic review. Eur Heart J 29:1807ā1818
Menasche P (2011) Cardiac cell therapy: lessons from clinical trials. J Mol Cell Cardiol 50:258ā265
Messina E, De Angelis L, Frati G, Morrone S, Chimenti S, Fiordaliso F, Salio M, Battaglia M, Latronico MV, Coletta M, Vivarelli E, Frati L, Cossu G, Giacomello A (2004) Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res 95:911ā921
Nikolova G, Strilic B, Lammert E (2006) The vascular niche and its basement membrane. Trends Cell Biol 17(1):19ā25
Oberpriller JO, Oberpriller JC (1974) Response of the adult newt ventricle to injury. J Exp Zool 187:249ā253
Ohlstein B, Kai T, Decotto E, Spradling A (2004) The stem cell niche: theme and variations. Curr Opin Cell Biol 16:693ā699
Owens GK (2007) Molecular control of vascular smooth muscle cell differentiation and phenotypic plasticity. Novartis Found Symp 283:174ā191
Pacilli A, Pasquinelli G (2009) Vascular wall resident Āprogenitor cells. A review. Exp Cell Res 315:901ā914
Pendyala L, Goodchild T, Gadesam RR, Chen J, Robinson K, Chronos N, Hou D (2008) Cellular cardiomyoplasty and cardiac regeneration. Curr Cardiol Rev 4(2):72ā80
Reffelmann T, Kƶnemann S, Kloner RA (2009) Promise of blood- and bone marrow-derived stem cell transplantation for functional cardiac repair. Putting it in perspective with existing therapy. J Am Coll Cardiol 53:305ā308
Rensen SSM, Doevendans PAFM, van Eys GJJM (2007) Regulation and characteristics of vascular smooth muscle cell phenotypic diversity. Neth Heart J 15(3):100ā108
Sainz J, Al Haj Zen A, Caligiuri G, Demerens C, Urbain D, Lemitre M, Lafont A (2006) Isolation of āside populationā progenitor cells from healthy arteries of adult mice. Arterioscler Thromb Vasc Biol 26(2):281ā286
Smith RR, Barile L, Cho HC, Leppo MK, Hare JM, Messina E, Giacomello A, Abraham MR, MarbĆ”n E (2007) Regenerative potential of cardiosphere derived cells expanded from percutaneous endomyocardial biopsy specimens. Circulation 115:896ā908
Tokac M, Aktan M, Ak A, Duman S, Tokgozoglu L, Aygul N, Paksoy Y, Porat Y (2010) Autologous transplantation of arterial cells improves cardiac function in a rabbit model of infarcted myocardium. Stem Cells Dev 19(6):927ā934
Torsney E, Xu Q (2011) Resident vascular progenitor cells. J Mol Cell Cardiol 50(2):304ā311
Traktuev DO, Merfeld-Clauss S, Li J, Kolonin M, Arap W, Pasqualini R, Johnstone BH, March KL (2008) A population of multipotent CD34-positive adipose stromal cells share pericyte and mesenchymal surface markers, reside in a periendothelial location, and stabilize endothelial networks. Circ Res 102:77ā85
Velican D, Velican C (1989) Coronary anatomy and microarchitecture as related to coronary atherosclerotic involvement. Med Interne 27(4):257ā262
Wurmser AE, Palmer TD, Gage FH (2004) Neuroscience. Cellular interactions in the stem cell niche. Science 304:1253ā1255
Zengin E, Chalajour F, Gehling UM, Ito WD, Treede H, Lauke H, Weil J, Reichenspurner H, Kilic N, ErgĆ¼n S (2006) Vascular wall resident progenitor cells: a source for postnatal vasculogenesis. Development 133:1543ā1551
Zhang H, Fazel S, Tian H, Mickle DAG, Weisel RD, Fujii T, Li R (2005) Increasing donor age adversely impacts beneficial effects of bone marrow but not smooth muscle myocardial cell therapy. Am J Physiol Heart Circ Physiol 289:H2089āH2096
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TokaƧ, M., Aktan, T.M. (2012). Cellular Cardiomyoplasty: Arterial Cells-Stem Cells Transplantation. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells, Volume 5. Stem Cells and Cancer Stem Cells, vol 5. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2900-1_10
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DOI: https://doi.org/10.1007/978-94-007-2900-1_10
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