Signaling Pathways in Cancer Stem Cells: Therapeutic Implications
Established therapeutic approaches for cancer do cause tumor shrinking but often fail to eradicate them, hypothetically due to the existence of cancer stem cells (CSC), which are quite resistant to radio- and chemotherapy due to certain intrinsic biological features. The surviving CSC population is suspected to account for tumor relapse that commonly occurs in patients. Aim of this chapter is to critically discuss upcoming therapies targeting CSC with particular emphasis on key signaling pathways involved in normal and cancer stem cells maintenance. Improved knowledge of the role of signaling pathways in CSC will be fundamental to understand the fine balancing between quiescence and proliferation in tumor initiating cells and to elaborate effective anti-cancer therapies.
KeywordsCancer Stem Cell Adenomatous Polyposis Coli Side Population Side Population Cell Normal Stem Cell
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