Skip to main content
SpringerLink
Log in

Intracranial Meningiomas: Role of Exogenous Hormones

  • Chapter
  • First Online:
Tumors of the Central Nervous System, Volume 7

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 7))

Abstract

Meningiomas express multiple hormone receptors including progesterone, estrogen, androgen, growth hormone, dopamine, and somatostatin. There is a growing body of knowledge regarding the particular roles that each hormone receptor may play in modulating meningioma growth metrics. Identification of progesterone and estrogen receptor balances has shown to be of prognostic significance for meningioma growth behavior. Growth hormone may also promote meningioma growth. Somatostatin, alternatively, has been shown in robust affinity towards meningioma identification for diagnostic purposes via radionucleotide imaging. It may be used to attenuate meningioma growth, as reported in both in vitro and clinical reports. This strong correlation with hormonal activity suggests that patients who are treated with exogenous hormones may develop meningiomas as a result. Understanding this association may help elucidate various treatment paradigms.

At this time, unequivocal evidence of exogenous hormone involvement in the growth of meningioma remains absent. Here, we present a current understanding on the role of exogenous hormones in meningioma biology and their association with meningioma in clinical practice. Available information suggests that patients being treated with exogenous progesterone, estrogen, or growth hormone be advised that they may be at increased risk for meningioma.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Arena S, Barbieri F, Thellung S, Pirani P, Corsaro A, Villa V, Dadati P, Dorcaratto A, Lapertosa G, Ravetti J, Spaziante R, Schettini G, Florio T (2004) Expression of somatostatin receptor mRNA in human meningiomas and their implication in in vitro antiproliferative activity. J Neurooncol 66:155–166

    Article  PubMed  Google Scholar 

  • Bickerstaff ER, Small JM, Guest IA (1958) The relapsing course of certain meningiomas in relation to pregnancy and menstruation. J Neurol Neurosurg Psychiatry 21:89–91

    Article  PubMed  CAS  Google Scholar 

  • Camacho-Arroyo I, González-Agüero G, Gamboa-Domínguez A, Cerbón MA, Ondarza R (2007) Progesterone receptor isoforms expression pattern in human chordomas. J Neurooncol 49:1–7

    Article  Google Scholar 

  • Chamberlain MC, Glantz MJ, Fadul CE (2007) Salvage therapy with long-acting somatostatin analogue. Neurology 69(10):969–973

    Article  PubMed  CAS  Google Scholar 

  • Claus EB, Black PM, Bondy ML, Calvocoressi L, Schildkraut JM, Wiemels JL, Wrensch M (2007) Exogenous hormone use and meningioma risk: what do we tell our patients? Cancer 110:471–476

    Article  PubMed  Google Scholar 

  • Claus EB, Park PJ, Carroll R, Chan J, Black PM (2008) Specific genes expressed in association with progesterone receptors in meningioma. Cancer Res 68:314–322

    Article  PubMed  CAS  Google Scholar 

  • Connaghan-Jones KD, Heneghan AF, Miura MT, Bain DL (2007) Thermodynamic analysis of progesterone receptor-promoter interactions reveals a molecular model for isoform-specific function. Proc Natl Acad Sci USA 13:2187–2192

    Article  Google Scholar 

  • Curto L, Squadrito S, Almoto B, Longo M, Granata F, Salpietro F, Torre ML, Marini F, Trimarchi F, Cannavo S (2007) MRI finding of simultaneous coexistence of growth hormone-secreting pituitary adenoma with intracranial meningioma and carotid artery aneurysms: report of a case. Pituitary 10(3):299–305

    Article  PubMed  Google Scholar 

  • Cushing H, Eisenhardt L (1938) Meningiomas: their classification, regional behavior, life history, and surgical end results. Charles C Thomas, Springfield, p 785

    Google Scholar 

  • Custer B, Longstreth WT, Phillips LE, Koepsell TD, Van Belle G (2006) Hormonal exposures and the risk of intracranial meningioma in women: a population-base case-control study. BMC Cancer 6:152

    Article  PubMed  Google Scholar 

  • Drake WM, Grossman AB, Hutson RK (2005) Effect of treatment with pegvisomant on meningioma growth in vivo. Eur J Endocrinol 152:161–162

    Article  PubMed  CAS  Google Scholar 

  • Gay E, Vuillez JP, Palombi O, Brard PY, Bessou P, Passagia JG (2005) Intraoperative and postoperative gamma detection of somatostatin receptors in bone-invasive en plaque meningiomas. Neurosurgery 57:107–113

    Article  PubMed  Google Scholar 

  • González-Agüero G, Ondarza R, Gamboa-Domínguez A, Cerbón MA, Camacho-Arroyo I (2001) Progesterone receptor isoforms expression pattern in human astrocytomas. Brain Res Bull 56:43–48

    Article  PubMed  Google Scholar 

  • Gruber T, Dare AO, Balos LL, Lele S, Fenstermaker R (2004) Multiple meningiomas arising during long-term therapy with the progesterone agonist megestrol acetate. Case report. J Neurosurg 100:328–331

    Article  PubMed  Google Scholar 

  • Grunberg SM, Weiss MH (1990) Lack of efficacy of megestrol acetate in the treatment of unresectable meningioma. J Neurooncol 8:61–65

    Article  PubMed  CAS  Google Scholar 

  • Grunberg SM, Daniels AM, Muensch H, Daniels JR, Bernstein L, Kortes V, Weiss MH (1987) Correlation of meningioma hormone receptor status with hormone sensitivity in a tumor stem-cell assay. J Neurosurg 66:405–408

    Article  PubMed  CAS  Google Scholar 

  • Hsu DW, Efird JT, Hedley-Whyte ET (1997) Progesterone and estrogen receptors in meningiomas: prognostic considerations. J Neurosurg 86:113–120

    Article  PubMed  CAS  Google Scholar 

  • Inoue T, Akahira J, Suzuki T, Darnel AD, Kaneko C, Takahashi K, Hatori M, Shirane R, Kumabe T, Kurokawa Y, Satomi S, Sasano H (2002) Progesterone production and actions in the human central nervous system and neurogenic tumors. J Clin Endocrinol Metab 87:5325–5331

    Article  PubMed  CAS  Google Scholar 

  • Jhawar BS, Fuchs CS, Colditz GA, Stampfer MJ (2003) Sex steroid hormone exposures and risk for meningioma. J Neurosurg 99:848–853

    Article  PubMed  CAS  Google Scholar 

  • Korhonen K, Raitanen J, Isola J, Haapasalo H, Salminen T, Auvinen A (2010) Exogenous sex hormone use and risk of meningioma: a population-based case control study in Finland. Cancer Causes Control 21(12):2149–2156

    Article  PubMed  CAS  Google Scholar 

  • McCutcheon IE, Flyvbjerg A, Hill H, Li J, Bennett WF, Scarlett JA, Friend KE (2001) Antitumor activity of the growth hormone receptor antagonist pegvisomant against human meningiomas in nude mice. J Neurosurg 94:487–492

    Article  PubMed  CAS  Google Scholar 

  • McGowan EM, Russell AJ, Boonyaratanakornkit V, Saunders DN, Lehrbach GM, Sergio CM, Musgrove EA, Edwards DP, Sutherland RL (2007) Progestins reinitiate cell cycle progression in antiestrogen-arrested breast cancer cells through the B-isoform of progesterone receptor. Cancer Res 67:8942–8951

    Article  PubMed  CAS  Google Scholar 

  • Michaud DS, Gallo V, Schlehofer B, Tjønneland A, Olsen A, Overvad K, Dahm CC, Kaaks R, Lukanova A, Boeing H, Schütze M, Trichopoulou A, Bamia C, Kyrozis A, Sacerdote C, Agnoli C, Palli D, Tumino R, Mattiello A, Bueno-de-Mesquita HB, Ros MM, Peeters PH, van Gils CH, Lund E, Bakken K, Gram IT, Barricarte A, Navarro C, Dorronsoro M, Sánchez MJ, Rodríguez L, Duell EJ, Hallmans G, Melin BS, Manjer J, Borgquist S, Khaw KT, Wareham N, Allen NE, Tsilidis KK, Romieu I, Rinaldi S, Vineis P, Riboli E (2010) Reproductive factors and exogenous hormone use in relation to risk of glioma and meningioma in a large European cohort study. Cancer Epidemiol Biomark Prev 19(10):2562–2569

    Article  CAS  Google Scholar 

  • Nakamura Y, Shimizu T, Ohigashi Y, Itou N, Ishikawa Y (2005) Meningioma arising in Werner syndrome confirmed by mutation analysis. J Clin Neurosci 12:503–506

    Article  PubMed  Google Scholar 

  • Nathoo N, Ugokwe K, Chang AS, Li L, Ross J, Suh JH, Vogelbaum MA, Barnett GH (2007) The role of 111indium-octreotide brain scintigraphy in the diagnosis of cranial, dural-based meningiomas. J Neurooncol 81:167–174

    Article  PubMed  Google Scholar 

  • Nicolato A (2004) 111Indium-octreotide brain scintigraphy: a prognostic factor in skull base meningiomas treated with gamma knife radiosurgery. Q J Nucl Med Mol Imaging 48(1):26–32

    PubMed  CAS  Google Scholar 

  • Piper JG, Follett KA, Fantin A (1994) Sphenoid wing meningioma progression after placement of a subcutaneous progesterone agonist contraceptive implant. Neurosurgery 34:723–725

    Article  PubMed  CAS  Google Scholar 

  • Pravdenkova S, Al-Mefty O, Sawyer J, Husain M (2006) Progesterone and estrogen receptors: opposing prognostic indicators in meningiomas. J Neurosurg 105:163–173

    Article  PubMed  CAS  Google Scholar 

  • Riemenschneider MJ, Perry A, Reifenberger G (2006) Histological classification and molecular genetics of meningiomas. Lancet Neurol 5(12):1045–1054

    Article  PubMed  CAS  Google Scholar 

  • Schoenberg BS, Christine BW, Whisnant JP (1975) Nervous system neoplasms and primary malignancies of other sites. The unique association between meningiomas and breast cancer. Neurology 25:705–712

    PubMed  CAS  Google Scholar 

  • Shabani N, Kuhn C, Kunze S, Schulze S, Mayr D, Dian D, Gingelmaier A, Schindelbeck C, Willgeroth F, Sommer H, Jenschke U, Friese K, Mylonas I (2007) Prognostic significance of oestrogen receptor alpha (ERalpha) and beta (ERbeta), progesterone receptor A (PR-A) and B (PR-B) in endometrial carcinomas. Eur J Cancer 43:2434–2444

    Article  PubMed  CAS  Google Scholar 

  • Shimizu J, Matsumoto M, Yamazaki E, Yasue M (2008) Spontaneous regression of an asymptomatic meningioma associated with discontinuation of progesterone agonist administration. Neurol Med Chir 48:227–230

    Article  Google Scholar 

  • Tung L, Mohamed MK, Hoeffler JP, Takimoto GS, Horwitz KB (1993) Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A-receptors. Mol Endocrinol 7:1256–1265

    Article  PubMed  CAS  Google Scholar 

  • Vadivelu S, Sharer L, Schulder M (2010) Regression of multiple intracranial meningiomas after cessation of long – term progesterone agonist therapy. J Neurosurg 112(5):920–924

    Article  PubMed  CAS  Google Scholar 

  • Van der Lely AJ, Hutson RK, Trainer PJ, Besser GM, Barkan AL, Katznelson L, Klibanski A, Herman-Bonert V, Melmed S, Vance ML, Freda PU, Stewart PM, Friend KE, Clemmons DR, Johannsson G, Stavrou S, Cook DM, Phillips LS, Strasburger CJ, Hackett S, Zib KA, Davis RJ, Scarlett JA, Thorner MO (2001) Long term treatment of acromegaly with pegvisomant, a growth hormone receptor antagonist. Lancet 358:1754–1759

    Article  PubMed  Google Scholar 

  • Verheijen FM, Sprong M, Jacobs HM, Donker GH, Amelink GJ, Thijssen JH, Blankenstein MA (2001) Progesterone receptor isoform expression in human meningiomas. Eur J Cancer 37:1488–1495

    Article  PubMed  CAS  Google Scholar 

  • Wigertz A, Lonn S, Mathiesen T, Ahlbom A, Hall P, Feychting M, the Swedish Interphone Study Group (2006) Risk of brain tumors associated with exposure to exogenous female sex hormones. Am J Epidemiol 164:629–636

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Hofstra North Shore-LIJ School of medicine, 300 Community Drive-9Tower, Manhasset, NY, 11030, USA

    Sudhakar Vadivelu & Michael Schulder

Authors
  1. Sudhakar Vadivelu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Michael Schulder
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Sudhakar Vadivelu .

Editor information

Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media B.V.

About this chapter

Cite this chapter

Vadivelu, S., Schulder, M. (2012). Intracranial Meningiomas: Role of Exogenous Hormones. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 7. Tumors of the Central Nervous System, vol 7. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2894-3_4

Download citation

  • DOI: https://doi.org/10.1007/978-94-007-2894-3_4

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-2893-6

  • Online ISBN: 978-94-007-2894-3

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation