Cyclin D1 Expression in Vestibular Schwannoma
Recent studies suggest a role for cyclin D1 in Schwann cell differentiation. The purpose of the study was to evaluate the relationship between cyclin D1 expression and clinical and histological features of vestibular schwannoma. Twenty-one vestibular schwannoma specimens were examined. Immunohistochemistry analysis was performed with anticyclin D1. Clinical charts, audiometric data, and MRI characteristics were reviewed as well as histological features. Cyclin D1 expression was found in 52% of cases. Cyclin D1 expression was more frequent in right sided tumors (p = 0.02), and in tumors with nuclear degenerative changes (p < 0.0001). Cyclin D1 expression, present in nearly half of the cases, may play a role in the development of these tumors. Further studies are needed to fully understand the contributions of histopathological and immunohistochemical factors to vestibular schwannoma biological activity.
KeywordsSchwann Cell Mantle Cell Lymphoma Malignant Mesothelioma Vestibular Schwannoma Vestibular Schwannomas
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