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Calcium Signaling pp 1175–1191Cite as

Proarrhythmic Atrial Calcium Cycling in the Diseased Heart

Part of the Advances in Experimental Medicine and Biology book series (AEMB,volume 740)

Abstract

During the last decades Ca2+ has been found to play a crucial role in cardiac arrhythmias associated with heart failure and a number of congenital arrhythmia syndromes. Recent studies demonstrated that altered atrial Ca2+ cycling may promote the initiation and maintenance of atrial fibrillation, the most common clinical arrhythmia that contributes significantly to population morbidity and mortality. This article describes physiological Ca2+ cycling mechanisms in atrial cardiomyocytes and relates them to fundamental cellular proarrhythmic mechanisms involving Ca2+ signaling abnormalities in the atrium during atrial fibrillation.

Keywords

  • Calcium
  • Atrial arrhythmias
  • Remodeling
  • Ion channels
  • Reentry
  • Triggered activity

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  • DOI: 10.1007/978-94-007-2888-2_53
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Fig. 53.1
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Acknowledgements

The author’s research is supported by the Deutsche Forschungsgemeinschaft (Do769/1-1-3, to DD), the German Federal Ministry of Education and Research (BMBF; Atrial Fibrillation Competence Network [01Gi0204] and German Center of Cardiovascular Research, both to DD), the European Union through the European Network for Translational Research in Atrial Fibrillation, (EUTRAF, FP7-HEALTH-2010, large-scale integrating project, Proposal No. 261057 to DD), the Canadian Institutes of Health Research (MOP44365, to SN) and the European-North American Atrial Fibrillation Research Alliance (ENAFRA) grant of Fondation Leducq (07CVD03, to DD and SN).

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Authors and Affiliations

  1. Division of Experimental Cardiology, Medical Faculty Mannheim, University of Heidelberg, Theodor-Kutzer-Ufer 1-3, 68167, Mannheim, Germany

    Niels Voigt & Dobromir Dobrev

  2. Montreal Heart Institute, University of Montreal and Research Center, 5000 Belanger Street E, Montreal, QC, Canada, H1T 1C8

    Stanley Nattel

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  1. Niels Voigt
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  2. Stanley Nattel
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  3. Dobromir Dobrev
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Correspondence to Dobromir Dobrev .

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  1. , Department of Clinical Sciences and Educ, Karolinska Institutet, Tulegatan 26, Stockholm, SE-118 83, Sweden

    Md. Shahidul Islam

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© 2012 Springer Science+Business Media B.V.

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Voigt, N., Nattel, S., Dobrev, D. (2012). Proarrhythmic Atrial Calcium Cycling in the Diseased Heart. In: Islam, M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 740. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2888-2_53

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