Abstract
Aim of this review is to give an overview and discuss recent findings on the role of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in the heart. Special attention is drawn to excitation-contraction coupling (ECC) and excitation-transcription coupling (ETC). Because CaMKII expression and activity are increased in cardiac hypertrophy, heart failure, and during arrhythmias both in animal models as well as in the human heart a clinical significance of CaMKII is implied.
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Supported by grants from the DFG through a Heisenberg-grant (MA 1982/4-1), a grant for a Clinical Research group KFO155 (MA 1982/2-1), and the Fondation Leducq Award to the Alliance for Calmodulin Kinase Signaling in Heart Disease.
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Maier, L.S. (2012). Ca2+/Calmodulin-Dependent Protein Kinase II (CaMKII) in the Heart. In: Islam, M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 740. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2888-2_30
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