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Calcium Around the Golgi Apparatus: Implications for Intracellular Membrane Trafficking

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Calcium Signaling

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 740))

Abstract

As with other complex cellular functions, intracellular membrane transport involves the coordinated engagement of a series of organelles and machineries; in the last couple of decades more importance has been given to the role of calcium (Ca2+) in the regulation of membrane trafficking, which is directly involved in coordinating the endoplasmic reticulum-to-Golgi-to-plasma membrane delivery of cargo. Consequently, the Golgi apparatus (GA) is now considered not just the place proteins mature in as they move to their final destination(s), but it is increasingly viewed as an intracellular Ca2+ store. In the last few years the mechanisms regulating the homeostasis of Ca2+ in the GA and its role in membrane trafficking have begun to be elucidated. Here, these recent discoveries that shed light on the role Ca2+ plays as of trigger of different steps during membrane trafficking has been reviewed. This includes recruitment of proteins and SNARE cofactors to the Golgi membranes, which are both fundamental for the membrane remodeling and the regulation of fusion/fission events occurring during the passage of cargo across the GA. I conclude by focusing attention on Ca2+ homeostasis dysfunctions in the GA and their related pathological implications.

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Abbreviations

Ca2+ :

Calcium ions

[Ca2+]cyt :

Free calcium ion concentration in the cell cytosol

[Ca2+]ext :

Free extracellular calcium ion concentration

[Ca2+]GA :

Free calcium ion concentration in the Golgi apparatus

CaR:

Ca2+ receptor

CGN:

Cis-Golgi network

COPI:

Coat protein I

ER:

Endoplasmic reticulum

GA:

Golgi apparatus

HDD:

Hailey-Hailey disease

IGF1R:

Insulin-like growth factor receptor

IP3R:

Inositol 1,4,5-trisphospahate receptor

NCS-1:

Neuronal calcium sensor 1

PLA2:

Phospholipase A2

PM:

Plasma membrane

SERCA:

Sarco/endoplasmic reticulum Ca2+-transport ATPase pump

SNARE:

Soluble N-ethylmaleimide-sensitive fusion factor attachment protein receptor

SPCA1:

Secretory pathway Ca2+-ATPase isoform 1

TGN:

Trans-Golgi network

VSMCs:

Vascular smooth muscle cells

VSVG:

Temperature sensitive variant of the G protein of vesicular stomatitis virus

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Acknowledgments

The author thanks Dr. Joshua S. Mylne for proofreading of the manuscript, Dr. Parashuraman Seetharaman for discussion and critical reading, and Dr. Giada Giacchetti for assistance with manuscript preparation and artworks.

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  1. Division of Molecular Cell Biology, Institute for Molecular Bioscience, The University of Queensland, 306 Carmody Road, 4072, Brisbane, St. Lucia, QLD, Australia

    Massimo Micaroni

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  1. , Department of Clinical Sciences and Educ, Karolinska Institutet, Tulegatan 26, Stockholm, SE-118 83, Sweden

    Md. Shahidul Islam

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Micaroni, M. (2012). Calcium Around the Golgi Apparatus: Implications for Intracellular Membrane Trafficking. In: Islam, M. (eds) Calcium Signaling. Advances in Experimental Medicine and Biology, vol 740. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2888-2_18

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