Skip to main content

Intraspinal Oncocytic Adrenocortical Adenoma: Diagnosis

  • Chapter
  • First Online:
  • 1147 Accesses

Part of the book series: Tumors of the Central Nervous System ((TCNS,volume 6))

Abstract

Oncocytic adrenocortical adenomas are rare non-functioning variants of adrenal cortical adenomas. To date at least seven intraspinal tumors have been observed. The tumors are positive for Melan A, synaptophysin, focally cytokeratins 8 and 18, while S-100, chromogranin and HMB45 are negative. Typically there is abundant mitochondria in electron microscopy. Differential diagnosis includes tumors with oncocytic changes as paraganglioma, meningioma, alveolar soft part sarcoma, granular cell tumor and carcinoma. An overview of these rare, but probably underdiagnosed intraspinal tumors is given.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  • Bisceglia M, Ludovico O, Di Mattia A, Ben-Dor D, Sandbank J, Pasquinelli G, Lau SK, Weiss LM (2004) Adrenocortical oncocytic tumors: report of 10 cases and review of the literature. Int J Surg Pathol 12:231–243

    Article  PubMed  Google Scholar 

  • Cassarino DS, Santi M, Arruda A, Patrocinio R, Tsokos M, Ghatak N, Quezado M (2004) Spinal adrenal cortical adenoma with oncocytic features: report of the first intramedullary case and review of the literature. Int J Surg Pathol 12:259–264

    Article  PubMed  Google Scholar 

  • Drut R, Quijano G, Altamirano ME, Jones MC, Maffessoli OB (2006) Vascular malformation and choroid plexus adrenal heterotopia: new findings in Beckwith-Wiedemann syndrome? Fetal Pediatr Pathol 25:191–197

    Article  PubMed  Google Scholar 

  • Karikari IO, Uschold TD, Selznick LA, Carter JH, Cummings TJ, Friedman AH (2006) Primary spinal intramedullary adrenal cortical adenoma associated with spinal dysraphism: case report. Neurosurgery 59:E1144

    Article  PubMed  Google Scholar 

  • Kepes JJ, O’Boynick P, Jones S, Baum D, McMillan J, Adams ME (1990) Adrenal cortical adenoma in the spinal canal of an 8-year-old girl. Am J Surg Pathol 14:481–484

    Article  PubMed  CAS  Google Scholar 

  • Kim SH, Paik S, Yoon DH, Kim TS (2001) Oncocy­toma of the spinal cord. Case report. J Neurosurg 94:310–312

    Article  PubMed  CAS  Google Scholar 

  • Lin BT, Bonsib SM, Mierau GW, Weiss LM, Medeiros LJ (1998) Oncocytic adrenocortical neoplasms: a report of seven cases and review of the literature. Am J Surg Pathol 22:603–614

    Article  PubMed  CAS  Google Scholar 

  • McLendon R, Cummings TJ (2006) Ectopias and hamartomas. In: Russell and Rubinstein’s pathology of tumors of the nervous system, 7th edn. Hodder Arnold, London, pp 613–621

    Google Scholar 

  • Meyer AW (1917) Spolia anatomica, addenda II: a congenital, intracranial, intra-dural adrenal. Anat Rec 12:43–50

    Article  Google Scholar 

  • Mitchell A, Scheithauer BW, Sasano H, Hubbard EW, Ebersold MJ (1993) Symptomatic intradural adrenal adenoma of the spinal nerve root: report of two cases. Neurosurgery 32:658–661

    Article  PubMed  CAS  Google Scholar 

  • Moran CA, Rush W, Mena H (1997) Primary spinal paragangliomas: a clinicopathological and immunohistochemical study of 30 cases. Histopathology 31:167–173

    Article  PubMed  CAS  Google Scholar 

  • Park DH, Park YK, Oh JI, Kwon TH, Chung HS, Cho HD, Suh YL (2002) Oncocytic paraganglioma of the cauda equina in a child. Case report and review of the literature. Pediatr Neurosurg 36:260–265

    Article  PubMed  Google Scholar 

  • Park HS, Jang KY, Kang MJ, Song KJ, Lee KB (2007) Oncocytoma of the spinal cord causing paraplegia – a case report. Spinal Cord 45:183–186

    Article  PubMed  CAS  Google Scholar 

  • Schittenhelm J, Ebner FH, Harter P, Bornemann A (2009) Symptomatic intraspinal oncocytic adrenocortical adenoma. Endocr Pathol 20:73–77

    Article  PubMed  Google Scholar 

  • Wiener MF, Dallgaard SA (1959) Intracranial adrenal gland; a case report. AMA Arch Pathol 67:228–233

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Jens Schittenhelm .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media B.V.

About this chapter

Cite this chapter

Schittenhelm, J. (2012). Intraspinal Oncocytic Adrenocortical Adenoma: Diagnosis. In: Hayat, M. (eds) Tumors of the Central Nervous System, Volume 6. Tumors of the Central Nervous System, vol 6. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2866-0_10

Download citation

  • DOI: https://doi.org/10.1007/978-94-007-2866-0_10

  • Published:

  • Publisher Name: Springer, Dordrecht

  • Print ISBN: 978-94-007-2865-3

  • Online ISBN: 978-94-007-2866-0

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics