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Development: In Vivo Pharmacology—Systems Biology in Health and Disease II

  • Aleš Prokop
  • Seth Michelson
Chapter
Part of the SpringerBriefs in Pharmaceutical Science & Drug Development book series (BRIEFSPSDD, volume 2)

Abstract

This chapter covers qualitative in vivo approaches in animals and man, which will help to develop in silico pharmacology and PK positions. Additionally, we cover RNA interference in this chapter even though it is largely an in vitro method for characterizing the dynamics of cell physiology. And though in silico pharmacology is only in a rudimentary state, it is vitally important for clinical model based drug design (MBDD) development (see Chap. 10).

Keywords

Humanize Mouse Animal Disease Model Xenobiotic Receptor Virtual Ligand Screening Adaptive Trial Design 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© The Author(s) 2012

Authors and Affiliations

  1. 1.Chemical and Biomolecular EngineeringVanderbilt UniversityNashvilleUSA
  2. 2.NanoDelivery International, s.r.o.Břeclav-PoštornáCzech Republic
  3. 3.Genomic Health IncRedwood CityUSA

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