Adult Neural Stem Cells; Identity and Regulation
Recent advances in stem cell biology raise our hope that loss of neurons can be replaced to restore disrupted neural circuits. To translate it into effective clinical applications, we need to gain a deep knowledge about how to generate, navigate, and integrate new neurons at the right time and in the right place. Neural stem cells exist in the adult mammalian brain throughout life and contribute to the production of new neurons every day. Understanding the underlying biology of adult neurogenesis will provide a framework for the development of stem cell therapy against various neurological disorders. Recent studies highlight the glial nature of adult neural stem cells, which is well conserved among vertebrates. The behavior of these glia-like stem cells is regulated by complex molecular mechanisms, but the Wnt/beta-catenin signaling is one of the most important pathways involved in multiple aspects of adult neurogenesis.
KeywordsNeural stem cells Adult neurogenesis Glia Wnt Beta-catenin
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