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Cancer Stem Cell Models and Role in Drug Discovery

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Stem Cells and Human Diseases

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Abstract

With the cementing of the cancer stem cell (CSC) concept, cancer ­biology and cancer drug discovery has attained a new avenue to approach cancer from. Studying the hierarchy of tumor tissue organization and how to inhibit the cell that resides at the very top of this hierarchy has opened up a new branch of tumor biology and given the opportunity to develop novel inhibitors that target cancer. With the ­discovery of CSCs in majority of cancer indications there seems to be a universal applicability of the concept. However, the CSC field is still at an early fledgling state and a lot more needs to be done in terms of understanding their emergence, maintenance, role in metastasis and determining the architecture of the tumor.

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Author information

Authors and Affiliations

  1. Genelux Corporation, 3030 Bunker Hill Street, Suite 310, San Diego, CA, 92109, USA

    Rohit Duggal, Boris Minev & Aladar Szalay

  2. Department of Biotechnology and Biosciences, University of Milano-Bicocca, Piazza della Scienza 2, I-20126, Milan, Italy

    Angelo Vescovi

Authors
  1. Rohit Duggal
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  2. Boris Minev
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  3. Angelo Vescovi
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  4. Aladar Szalay
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Corresponding author

Correspondence to Aladar Szalay .

Editor information

Editors and Affiliations

  1. , Pharmacology and Toxicology, University of Kansas Medical Center, Rainbow Blvd 3901, Kansas City, 66160, Kansas, USA

    Rakesh Srivastava

  2. , Pathology and Laboratory Medicine, University of Kansas Medical Center, Rainbow Blvd 3901, Kansas City, 66160, Kansas, USA

    Sharmila Shankar

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Duggal, R., Minev, B., Vescovi, A., Szalay, A. (2012). Cancer Stem Cell Models and Role in Drug Discovery. In: Srivastava, R., Shankar, S. (eds) Stem Cells and Human Diseases. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2801-1_10

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