Cancer Stem Cells: Novel Target Using Dietary Components for Prevention and Treatment

  • Animesh Dhar
  • Laura Fogt
  • Dharmalingam Subramaniam
  • Shrikant Anant
Chapter

Abstract

Cancer is the second leading cause of mortality in the United States and no significant treatment is currently available. Although an increasing number of therapeutic options exist for patients with advanced disease, their efficacy is time limited and non-curative. Presently approximately close to 60% of cancer patients in the United States are believed to utilize therapies derived from plants, herbs, flowers, or nutrients either exclusively or concurrently with traditional chemotherapy or radiation therapy. A growing body of evidence suggests that cancer stem cells within a solid tumor initiate and sustain tumor growth and could be quiescent even after therapeutic intervention by common anti-cancer drugs. Identification of important signaling pathways that regulate cancer stem cells could lead to novel targets for drug intervention. Dietary compounds have been shown to interfere in cancer stem cell related pathways and therefore offer a promising approach for prevention.

Keywords

Acute Myeloid Leukemia Cancer Stem Cell Adenomatous Polyposis Coli Sonic Hedgehog Adenomatous Polyposis Coli Gene 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

Work cited from our laboratory was supported by the US PHS grant CA109269 and CA135559, awarded by the National Cancer Institute. Contributions of the present and past members of the TOSA and CA151727 to AD Anant laboratory are greatly appreciated.

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Animesh Dhar
    • 1
  • Laura Fogt
    • 2
  • Dharmalingam Subramaniam
    • 3
  • Shrikant Anant
    • 3
  1. 1.Department of Cancer Biology, Cancer CenterUniversity of Kansas Medical CenterKansas CityUSA
  2. 2.Department of Molecular and Integrative PhysiologyUniversity of Kansas Medical CenterKansas CityUSA
  3. 3.Department of Molecular and Integrative Physiology, Cancer CenterUniversity of Kansas Medical CenterKansas CityUSA

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