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Global Overview of the Role of Nutraceuticals in Cancer


Cancer is a chronic disease of the genome that is influenced by nutritional factors at many stages of carcinogenesis, promotion and progression. A number of studies have demonstrated that dietary factors affect cancer risk. Previously these investigations have focused on macro- and micronutrients but more recent studies have explored the actions of non-nutritional phytochemicals and nutraceuticals. Investigations of the mechanisms of action of phytonutrients have led to pre-clinical studies with promising results. In the post-genomic era, the application of “omic” technologies provides further advances in nutraceutical research by utilizing integrative systems biology. In the future, well-designed clinical trials will help elucidate the role of nutraceuticals in the therapy and prevention of cancer and the role of complementary and alternative medicine (CAM) therapies in cancer management.


  • Dietary Supplement
  • Functional Food
  • Personalized Nutrition
  • Related Lifestyle Factor
  • World Cancer Research Fund

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  • DOI: 10.1007/978-94-007-2630-7_1
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American Institute for Cancer Research


Complementary and Alternative Medicine


Computer Access to Research on Dietary Supplements


Centers for Disease Control and Prevention


Dietary Guidelines for Americans


Dietary Supplement Health and Education Act


The Foundation for Innovation in Medicine


National Cancer Institute


United States Department of Agriculture


United States Food and Drug Administration


United States Department of Health and Human Services


National Institutes of Health


  • Barnes PM, Bloom B, Nahin R (2008) Complementary and alternative medicine use among adults and children: United States, 2007. CDC National Health Statistics Report #12

    Google Scholar 

  • DeFelice SL (2002) FIM rationale and proposed guidelines for the Nutraceutical Research & Education Act – NREA. Foundation for Innovation of Medicine. Accessed May 5 2011

  • Deng GE, Frenkel M, Cohen L et al (2009) Evidence-based clinical practice guidelines for integrative oncology: complementary therapy and botanicals. J Soc Integr Oncol 7:85–120

    PubMed  Google Scholar 

  • Eisenberg DM, Davis RB, Ettner SL et al (1998) Trends in alternative medicine use in the United States, 1990–1997: results from a follow up national survey. JAMA 280:1569–1575

    PubMed  CrossRef  CAS  Google Scholar 

  • Go VLW, Wong DA, Wang Y et al (2004) Diet and cancer prevention: evidence-based medicine to genomic medicine. J Nutr 134:3513S–3516S

    PubMed  CAS  Google Scholar 

  • Go VLW, Nguyen CTH, Harris DM et al (2005) Nutrient-gene interaction: metabolic genotype-phenotype relationship. J Nutr 135:3016S–3020S

    PubMed  CAS  Google Scholar 

  • Greenwald P, Milner JA, Anderson DE et al (2002) Micronutrients in cancer chemoprevention. Cancer Metastasis Rev 21(3–4):217–230

    PubMed  CrossRef  CAS  Google Scholar 

  • Harris DM, Go VLW (2006) How dietary components protect from cancer. In: Awad AB, Bradford PG (eds) Nutrition and cancer prevention. CRC Press, Boca Raton, FL, pp. 27–74

    Google Scholar 

  • Harris DM, Srihari P, Go VLW (2011) Pancreatic cancer prevention and the 2010 dietary guidelines for Americans. Pancreas 40(5):641–643

    PubMed  CrossRef  Google Scholar 

  • Hasler CM, Brown AC (2009) Position of the American Dietetic Association: functional foods. J Am Diet Assoc 109:735–746

    PubMed  CrossRef  Google Scholar 

  • Huang Q, Yu H, Ru Q (2010) Bioavailability and delivery of nutraceuticals using nanotechnology. J Food Sci 75(1):R50–R57

    PubMed  CrossRef  CAS  Google Scholar 

  • Lee WNP, Wahjudi PN, Xu J et al (2010) Tracer-based metabolomics: concepts and practices. Clin Biochem 43:1269–1277

    CrossRef  CAS  Google Scholar 

  • National Cancer Institute (2011) Nutrition in Cancer Care (PDQ) Nutrition therapy. National Cancer Institute. Accessed May 6, 2011

  • National Nutraceutical Center (2011) What are nutraceuticals? Accessed June 20 2011

  • Office of Dietary Supplements, National Institutes of Health (2011) Dietary supplements: background information. Retrieved 20 June 2011

  • Pérez-Jiménez J, Fezeu L, Touvier M et al (2011) Dietary intake of 337 polyphenols in French adults. Am J Clin Nutr 93:1220–1228

    PubMed  CrossRef  Google Scholar 

  • Picciano MF, Cohen BE, Thomas PR (2006) Dietary supplements in cancer prevention and therapy. In: Heber D, Blackburn GL, Go VLW et al (eds) Nutritional oncology, 2nd edn. Elsevier, San Diego, CA, pp. 507–579

    Google Scholar 

  • Regan KS, Wambogo EA, Haggans CJ (2011) NIH and USDA funding of dietary supplement research, 1999–2007. J Nutr 141:1–3

    PubMed  CrossRef  CAS  Google Scholar 

  • Sarkar FH (2010) Preface. Cancer Metastasis Rev 29:381–382. doi:10.1007/s 1055-010-9243-2

    PubMed  CrossRef  Google Scholar 

  • Simone CB II, Simone LM, Simone V et al (2007) Antioxidants and other nutrients do not interfere with chemotherapy or radiation therapy and can increase kill and increase survival, part 2. Altern Ther Health Med 13:40–47

    PubMed  Google Scholar 

  • U.S. Department of Agriculture and U.S. Department of Health and Human Services (2005) Dietary guidelines for Americans, 2005, 6th edn. Government Printing Office, Washington, DC

    Google Scholar 

  • U.S. Department of Agriculture and U.S. Department of Health and Human Services (2010) Dietary guidelines for Americans, 2010, 7th edn. Government Printing Office, Washington, DC

    Google Scholar 

  • U.S. Food and Drug Administration (2011) Overview of dietary supplements. U.S. Food and Drug Administration. Accessed 5 May 2011

  • van Tonder E, Herselman MG, Visser J (2009) The prevalence of dietary-related complementary and alternative therapies and their perceived usefulness among cancer patients. J Hum Nutr Diet 22:528–535

    PubMed  CrossRef  Google Scholar 

  • World Cancer Research Fund/American Institute for Cancer Research (2007) Food, nutrition, physical activity, and the prevention of cancer. AICR, Washington, DC

    Google Scholar 

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Correspondence to Vay Liang W. Go .

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Go, V.L.W., Harris, D.M., Srihari, P. (2012). Global Overview of the Role of Nutraceuticals in Cancer. In: Sarkar, F. (eds) Nutraceuticals and Cancer. Springer, Dordrecht.

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