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Surface Modification of Biodegradable Polyesters for Soft and Hard Tissue Regeneration

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Book cover Thin Films and Coatings in Biology

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

Synthetic biodegradable polyesters are commonly used in biomedical applications, especially as three-dimensional porous scaffolds for soft and hard tissue engineering. In addition to straightforward fabrication procedures, good mechanical strength and adjustable degradation properties all contribute to the appeal of these polymers. Still, scaffolds synthesized from polyesters are hydrophobic in nature and lack cell recognition signals. Coating or modifying their surface with molecules that enhance cellular adhesion and activity is therefore necessary to make them suitable as biomaterials, while preserving their bulk properties. This chapter reviews current strategies used to modify the surface of polyester-based scaffolds, with a specific focus on the modifications necessary to stimulate soft and hard tissue regeneration. The methods reviewed mostly involve two steps. During the first step, the polymer hydrophilicity is increased by generating carboxylic, amino or hydroxyl groups on the surface by either chemically or photochemically breaking the polymeric ester bonds, or by plasma treatment. This step also allows introducing functional groups on the polymeric surface, which can be used as anchors to bind biomolecules in the next step. In the second step, biomolecules of different types are bound to the previously modified polymer surface, to stimulate a specific tissue response. After providing an overview and many recent examples of the strategies used to achieve both steps, the chapter concludes by summarizing the main achievements to date and the challenges that still remain open.

Hesameddin Mahjoubi and Sara Abdollahi contributed equally to this chapter.

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  1. Materials Engineering, McGill University, 3610 University St, Montreal, QC, H3A 0C5, Canada

    Hesameddin Mahjoubi, Sara Abdollahi & Marta Cerruti

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  1. Hesameddin Mahjoubi
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  2. Sara Abdollahi
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  3. Marta Cerruti
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  1. Group NanoXplore Inc., Montreal, Québec, Canada

    Soroush Nazarpour

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Mahjoubi, H., Abdollahi, S., Cerruti, M. (2013). Surface Modification of Biodegradable Polyesters for Soft and Hard Tissue Regeneration. In: Nazarpour, S. (eds) Thin Films and Coatings in Biology. Biological and Medical Physics, Biomedical Engineering. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2592-8_7

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