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Medical Applications of Synchrotron Radiation

Exploring New Paths in Radiotherapy

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Radiation Damage in Biomolecular Systems

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

This chapter describes the state-of-art of synchrotron radiation therapies in the treatment of radioresistant tumors. The tolerance of the surrounding healthy tissue severely limits the achievement of a curative treatment for some brain tumors, like gliomas. This restriction is especially important in children, due to the high risk of complications in the development of the central nervous system. In addition, the treatment of tumors close to an organ at risk, like the spinal cord, is also restrained. One possible solution is the development of new radiotherapy techniques would exploit radically different irradiation modes, as it is the case of synchrotron radiotherapies. Their distinct features allow to modify the biological equivalent doses. In this chapter the three new approaches under development at the European Synchrotron Radiation Facility (ESRF), in Grenoble (France), will be described, namely: stereotactic synchrotron radiation therapy, microbeam radiation therapy and minibeam radiation therapy. The promising results obtained in the treatment of high grade brain tumors in preclinical studies have paved the way to the forthcoming clinical trials, currently in preparation.

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Author information

Authors and Affiliations

  1. ID17 Biomedical Beamline, European Synchrotron Radiation Facility, 38043, Grenoble, France

    Yolanda Prezado & Immaculada Martínez-Rovira

  2. Institut de Técniques Energètiques, Universitat Politècnica de Catalunya, E-08028, Barcelona, Spain

    Immaculada Martínez-Rovira

Authors
  1. Yolanda Prezado
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  2. Immaculada Martínez-Rovira
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the ID17 Biomedical Beamline (ESRF)

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Correspondence to Yolanda Prezado .

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Editors and Affiliations

  1. , Consejo Superior de Investigaciones Cien, Instituto de Física Fundamental (IFF), Serrano 113-bis, Madrid, 28006, Spain

    Gustavo García Gómez-Tejedor

  2. Consejo Superior de Investigaciones Cien, Instituto de Física Fundamental (IFF), Serrano 113bis, Madrid, 28006, Spain

    Martina Christina Fuss

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Prezado, Y., Martínez-Rovira, I., the ID17 Biomedical Beamline (ESRF). (2012). Medical Applications of Synchrotron Radiation. In: García Gómez-Tejedor, G., Fuss, M. (eds) Radiation Damage in Biomolecular Systems. Biological and Medical Physics, Biomedical Engineering. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2564-5_26

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  • DOI: https://doi.org/10.1007/978-94-007-2564-5_26

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