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Introduction

  • Karin B. Michels
Chapter

Abstract

This book joins two fi elds, epidemiology and epigenetics, to take advantage of their respective strengths in creating the science of epigenetic epidemiology. Epidemiology is the study of the frequency, distribution, and determinants of health and disease in humans. As a science fundamental to the study of public health, epidemiology is concerned with the prevention and effective control of disease.

Keywords

Assisted Reproductive Technology Epigenetic Mechanism Disease Epidemic Epigenetic Variation Epigenetic Profile 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. 1.
    Gordis L (2009) Epidemiology, 4th edn. Saunders, Elsevier, PhiladelphiaGoogle Scholar
  2. 2.
    Waterland RA, Michels KB (2007) Epigenetic epidemiology of the developmental origins hypothesis. Annu Rev Nutr 27:363–388PubMedCrossRefGoogle Scholar
  3. 3.
    Michels KB (2010) The promises and challenges of epigenetic epidemiology. Exp Gerontol 45:297–301PubMedCrossRefGoogle Scholar
  4. 4.
    Jaenisch R, Bird A (2003) Epigenetic regulation of gene expression: how the genome integrates intrinsic and environmental signals. Nat Genet 33(Suppl):245–254PubMedCrossRefGoogle Scholar
  5. 5.
    Cruz-Correa M, Zhao R, Oviedo M, Bernabe RD, Lacourt M, Cardona A et al (2009) Temporal stability and age-related prevalence of loss of imprinting of the insulin-like growth factor-2 gene. Epigenetics 4:114–118PubMedCrossRefGoogle Scholar
  6. 6.
    Wilson VL, Jones PA (1983) DNA methylation decreases in aging but not in immortal cells. Science 220:1055–1057PubMedCrossRefGoogle Scholar
  7. 7.
    Issa JP, Ottaviano YL, Celano P, Hamilton SR, Davidson NE, Baylin SB (1994) Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet 7:536–540PubMedCrossRefGoogle Scholar
  8. 8.
    Bjornsson HT, Sigurdsson MI, Fallin MD, Irizarry RA, Aspelund T, Cui H et al (2008) Intra-individual change over time in DNA methylation with familial clustering. JAMA 299:2877–2883PubMedCrossRefGoogle Scholar
  9. 9.
    Christensen BC, Marsit CJ, Kelsey KT (2012) Chapter 12: Influence of environmental factors on the epigenome. In: Michels KB (ed). Epigenetic Epidemiology, Springer 197–224Google Scholar

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.Obstetrics and Gynecology Epidemiology Center, Department of Obstetrics, Gynecology and Reproductive BiologyBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA
  2. 2.Department of EpidemiologyHarvard School of Public HealthBostonUSA

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