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Inorganic Nanoparticle as a Carrier for Hepatitis B Viral Capsids

Inorganic Nanoparticle as a Viral Capsid Carrier
  • Yu. Dekhtyar
  • M. RomanovaEmail author
  • A. Kachanovska
  • D. Skrastiņa
  • R. Reinhofa
  • P. Pumpens
  • A. Patmalnieks
Conference paper
Part of the NATO Science for Peace and Security Series A: Chemistry and Biology book series (NAPSA)

Abstract

Virus like particles (VLP) are used to transport immune response-modulating agents to target cells to treat them. In order to deliver a high concentration of VLP to the cell, a number of VLP can be attached to a nanoparticle to be used as a nanolorry. In this study, SiO2 nanoparticles were attached to Hepatitis B VLP. Spectrophotometry measurements, electron, and fluorescent microscopy evidence showed that the SiO2 – Hepatitis B VLP complexes were formed.

Keywords

Virus like particles Silica nanoparticles Nanolorry Immunomodulation 

References

  1. 1.
    Virus Particle Explorer. Human Hepatitis B Viral Capsid. http://viperdb.scripps.edu/info_page.php?VDB=1qgt
  2. 2.
    He-sheng C, Zhen-ya S, Li-hui X (2004) Properties of nano SiO2 modified PVF adhesive. J Wuhan Univ Technol Mater Sci Ed 19:73–75CrossRefGoogle Scholar
  3. 3.
    Sealy C (2006) Silica key to drug delivery. Nano Today 1:19CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Yu. Dekhtyar
    • 1
  • M. Romanova
    • 2
    Email author
  • A. Kachanovska
    • 2
  • D. Skrastiņa
    • 1
  • R. Reinhofa
    • 1
  • P. Pumpens
    • 1
  • A. Patmalnieks
    • 3
  1. 1.Biomedical Research and Study CentreRigaLatvia
  2. 2.Institute of Biological Engineering and NanotechnologyRiga Technical UniversityRigaLatvia
  3. 3.University of LatviaRigaLatvia

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