Inorganic Nanoparticle as a Carrier for Hepatitis B Viral Capsids
Virus like particles (VLP) are used to transport immune response-modulating agents to target cells to treat them. In order to deliver a high concentration of VLP to the cell, a number of VLP can be attached to a nanoparticle to be used as a nanolorry. In this study, SiO2 nanoparticles were attached to Hepatitis B VLP. Spectrophotometry measurements, electron, and fluorescent microscopy evidence showed that the SiO2 – Hepatitis B VLP complexes were formed.
KeywordsVirus like particles Silica nanoparticles Nanolorry Immunomodulation
- 1.Virus Particle Explorer. Human Hepatitis B Viral Capsid. http://viperdb.scripps.edu/info_page.php?VDB=1qgt