Synthesis of Hollow Silica Microspheres with High-Developed Surface Area

Synthesis of Hollow Silica Microspheres
  • I. Bei
  • A. Tolstov
  • A. Ishchenko
Conference paper
Part of the NATO Science for Peace and Security Series A: Chemistry and Biology book series (NAPSA)


Hollow silica microspheres (HSM), as efficient drug delivery carriers, were successfully prepared via a facile water-in-oil emulsion method using water glass precursor. The kinetics of drug release in aqueous medium was simulated using water-soluble erythrosine. Hollow silica microspheres show intensive release of active component at the beginning stages of introduction into aqueous (organism-imitating) conditions. Release rate of the model compound decreased and desorption time increased in the follow range: hollow silica microspheres > porous silica microparticles > silica nanoparticles.


Silica microspheres Carriers Absorbents Controlled release 


  1. 1.
    Wang S (2009) Ordered mesoporous materials for drug delivery. Micropor Mesopor Mater 117(1):1–9CrossRefGoogle Scholar
  2. 2.
    Fujiwara M, Shiokawa K, Tanaka Y, Nakahara Y (2004) Preparation and formation mechanism of silica microcapsules (hollow sphere) by water/oil/water interfacial reaction. Chem Mater 16(25):5420–5426CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.Institute of Macromolecular Chemistry of the NAS of UkraineKyivUkraine

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