Proteomic Characterization of Mesenchymal Stem Cell-Like Populations Derived from Various Tissue Types

  • Krzysztof M. Mrozik
  • Jimin Xiong
  • Peter S. Zilm
  • Stan Gronthos
  • P. Mark Bartold
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 3)


The evolution of proteomics has led to its application in identifying biomarkers of biological processes and pathways including signal transduction and cell development. Proteomic technologies are increasingly utilized to define the molecular mechanisms controlling mesenchymal stem/stromal cell (MSC) self-renewal, multipotency and fate. Bone marrow-derived MSCs are highly promising candidates in regenerative medicine based on their high proliferative capacity, multi-lineage differentiation potential and immunomodulatory properties. Recently, equivalent MSC-like populations have also been isolated from adipose, dental and various feto-maternal tissues. This chapter discusses the current technologies available for proteomic analysis and the studies performed on tissue-specific MSC-like populations to date.


Adipose tissue Bone marrow Periodontal ligament Dental pulp Umbilical cord blood Mesenchymal stem cells (MSCs) Proteomics 


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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  • Krzysztof M. Mrozik
    • 1
  • Jimin Xiong
    • 1
  • Peter S. Zilm
    • 1
  • Stan Gronthos
    • 2
  • P. Mark Bartold
    • 1
  1. 1.Colgate Australian Clinical Dental Research Centre, Dental SchoolThe University of AdelaideAdelaideAustralia
  2. 2.Mesenchymal Stem Cell Group, Department of Haematology/Centre for Stem Cell ResearchRobinson Institute, Discipline of Medicine, SA Pathology/The University of AdelaideAdelaideAustralia

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