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Stem Cells and Cancer Stem Cells,Volume 3 pp 317–325Cite as

Mesenchymal Stem Cell-Dependent Formation and Repair of Tendon-Bone Insertions

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Part of the book series: Stem Cells and Cancer Stem Cells ((STEM,volume 3))

Abstract

The repair of tendon and ligament injuries or even entire joint replacements after trauma, inflammation, or degeneration still presents a major clinical challenge to orthopaedic medicine. Soft tissues like cartilage, tendons and ligaments are poorly vascularized and heal slowly. In addition, healing often leads to the formation of fibrous, scarry tissue which lacks the original flexibility and biomechanical properties. Tendon-to-bone healing is a rather slow process and involves complex biological activities between these nonhomogenous soft and hard tissues. We will here review recent progress in the management of musculo-skeletal disorders of the joints specifically focussing on stem cell-dependent approaches for the repair of tendon-to-bone junctions.

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Acknowledgement

The authors gratefully acknowledge the discussions with A. Hoffmann, Department of Trauma Surgery, Medical School Hannover, Germany.

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Authors and Affiliations

  1. Inflammation and Regeneration, Helmholtz Centre for Infection Research (HZI), Braunschweig, Germany

    Virginia Seiffart & Sandra Laggies

  2. Signaling and Gene Regulation, Helmholtz Centre for Infection Research (HZI), 38124, Braunschweig, Germany

    Gerhard Gross

Authors
  1. Virginia Seiffart
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  2. Sandra Laggies
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  3. Gerhard Gross
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Corresponding author

Correspondence to Gerhard Gross .

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Editors and Affiliations

  1. , Kean University, Room 213, Library building, Morris Avenue 1000, Union, 07083, New Jersey, USA

    M.A. Hayat

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Seiffart, V., Laggies, S., Gross, G. (2012). Mesenchymal Stem Cell-Dependent Formation and Repair of Tendon-Bone Insertions. In: Hayat, M. (eds) Stem Cells and Cancer Stem Cells,Volume 3. Stem Cells and Cancer Stem Cells, vol 3. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2415-0_32

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