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Human Fetal Mesenchymal Stem Cells for Prenatal and Postnatal Transplantation

  • Mark S.K. Chong
  • Jerry K.Y. Chan
Chapter
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 3)

Abstract

Mesenchymal Stem Cells (MSC) isolated from early-mid-gestation fetal tissue are highly proliferative and capable of differentiation towards fat, bone, cartilage, muscle and oligodendrocytes. In addition, these cells exhibit several key clinical advantages over their adult counterparts, including increased proliferation capacity, greater plasticity and unique immunological characteristics. More recently, fetal MSC have been shown to home to and rescue degenerative tissue, raising the possibility of using fetal MSC for regenerative therapeutics. Consequently, fetal MSC have been studied for a range of potential clinical applications including stem cell or gene therapy for the correction of genetic deficiencies, tissue engineering and the management of immune disorders.

Keywords

Fetal MSC Prenatal Postnatal Transplantation Bone marrow 

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.Experimental Fetal Medicine Group, Department of Obstetrics and Gynecology, Yong Loo Lin School of MedicineNational University of Singapore and National University Hospital SystemSingaporeSingapore

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