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Mesenchymal Stem Cells: Role for Delivering Nanoparticles to Brain Tumors

  • Mathilde Roger
  • Anne Clavreul
  • Philippe Menei
Chapter
Part of the Stem Cells and Cancer Stem Cells book series (STEM, volume 3)

Abstract

The prognosis of patients with malignant glioma remains extremely poor, despite surgery and improvements in radio- and chemo-therapies. Since the last decade, stem cells with a specific tropism for brain tumors such as mesenchymal stem cells (MSCs), have been considered as therapeutic cellular vectors to treat glioma. MSCs have been already used to deliver bioactive molecule after virus modification in experimental glioma models, however, the use of virus is not without risk in human. Nanocarrier systems like nanoparticles (NPs) are a promising tool to substitute viral vectors as they protect the therapeutic agent and allow its sustained release. However, new paradigms allowing tumor specific targeting and extensive intratumoral distribution must be developed to efficiently deliver NPs. Knowing the tropism of MSCs for brain tumors, these cells could serve as cell carriers for the transportation and local release of NPs in brain tumors.

Keywords

Mesenchymal stem cells Nanoparticles Brain Glioma Nanocarrier Tropism 

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Copyright information

© Springer Science+Business Media B.V. 2012

Authors and Affiliations

  1. 1.INSERM Unit 646, IBS-CHU Angers, 4, rue LarreyUniversité d’AngersAngersFrance

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