Mesenchymal Stem Cells: Role for Delivering Nanoparticles to Brain Tumors
The prognosis of patients with malignant glioma remains extremely poor, despite surgery and improvements in radio- and chemo-therapies. Since the last decade, stem cells with a specific tropism for brain tumors such as mesenchymal stem cells (MSCs), have been considered as therapeutic cellular vectors to treat glioma. MSCs have been already used to deliver bioactive molecule after virus modification in experimental glioma models, however, the use of virus is not without risk in human. Nanocarrier systems like nanoparticles (NPs) are a promising tool to substitute viral vectors as they protect the therapeutic agent and allow its sustained release. However, new paradigms allowing tumor specific targeting and extensive intratumoral distribution must be developed to efficiently deliver NPs. Knowing the tropism of MSCs for brain tumors, these cells could serve as cell carriers for the transportation and local release of NPs in brain tumors.
KeywordsMesenchymal stem cells Nanoparticles Brain Glioma Nanocarrier Tropism
- Roger M, Clavreul A, Huynh NT, Passirani C, Schiller P, Vessieres A, Montero-Menei C, Menei P (2011b) Ferro-ciphenol lipid nanocapsule delivery by mesenchymal stromal cells in brain tumor therapy. Int J Pharm. doi:10.1016/j.ijpharm.2011.04.058Google Scholar
- Stupp R, Hegi ME, Mason WP, van den Bent MJ, Taphoorn MJ, Janzer RC, Ludwin SK, Allgeier A, Fisher B, Belanger K, Hau P, Brandes AA, Gijtenbeek J, Marosi C, Vecht CJ, Mokhtari K, Wesseling P, Villa S, Eisenhauer E, Gorlia T, Weller M, Lacombe D, Cairncross JG, Mirimanoff RO (2009) Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial. Lancet Oncol 10(5):459–466PubMedCrossRefGoogle Scholar
- Yin J, Kim JK, Moon JH, Beck S, Piao D, Jin X, Kim SH, Lim YC, Nam DH, You S, Kim H, Choi YJ (2011) hMSC-mediated concurrent delivery of endostatin and carboxylesterase to mouse xenografts suppresses glioma initiation and recurrence. Mol Ther 19(6):1161–1169Google Scholar
- Yukawa H, Kagami Y, Watanabe M, Oishi K, Miyamoto Y, Okamoto Y, Tokeshi M, Kaji N, Noguchi H, Ono K, Sawada M, Baba Y, Hamajima N, Hayashi S (2010) Quantum dots labeling using octa-arginine peptides for imaging of adipose tissue-derived stem cells. Biomaterials 31(14):4094–4103PubMedCrossRefGoogle Scholar